Nunzia Esposito, Giulio Viceconte, Lidia Festa, Francesco Antimo Alfè, Canio Carriero, Alessio Vinicio Codella, Antonio Glielmo, Luigi Forgione, Antonio Riccardo Buonomo, Franco Carmine Muccio, Marcello Lamberti, Roberto Alfano, Maria Grazia Coppola, Angelo Salomone Megna, Ivan Gentile
{"title":"2024年8 - 9月意大利坎帕尼亚爆发人类神经侵入性西尼罗病毒感染。","authors":"Nunzia Esposito, Giulio Viceconte, Lidia Festa, Francesco Antimo Alfè, Canio Carriero, Alessio Vinicio Codella, Antonio Glielmo, Luigi Forgione, Antonio Riccardo Buonomo, Franco Carmine Muccio, Marcello Lamberti, Roberto Alfano, Maria Grazia Coppola, Angelo Salomone Megna, Ivan Gentile","doi":"10.1177/15303667251360262","DOIUrl":null,"url":null,"abstract":"<p><p><b><i>Background:</i></b> West Nile Virus (WNV) infection is endemic in Italy, but it has rarely reported in humans in Southern Italy. We report the first human outbreak of WNV infection in the Campania region, Italy. <b><i>Results:</i></b> Five confirmed and seven probable cases of WNV were identified from August to September 2024. Predominantly affecting elderly males with comorbidities, all but one patient developed West Nile neuroinvasive disease, presenting with fever and impaired consciousness. Remdesivir was administered off-label in four cases, potentially reducing hospitalization and improving outcomes. Mortality was limited to two cases, attributed to bacterial infections. <b><i>Conclusions:</i></b> The outbreak underscores the importance of heightened surveillance in Italy and raises the potential for remdesivir in WNV treatment.</p>","PeriodicalId":23683,"journal":{"name":"Vector borne and zoonotic diseases","volume":" ","pages":"565-567"},"PeriodicalIF":2.1000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Outbreak of Human Neuroinvasive West Nile Virus Infection in Campania, Italy, August-September 2024.\",\"authors\":\"Nunzia Esposito, Giulio Viceconte, Lidia Festa, Francesco Antimo Alfè, Canio Carriero, Alessio Vinicio Codella, Antonio Glielmo, Luigi Forgione, Antonio Riccardo Buonomo, Franco Carmine Muccio, Marcello Lamberti, Roberto Alfano, Maria Grazia Coppola, Angelo Salomone Megna, Ivan Gentile\",\"doi\":\"10.1177/15303667251360262\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p><b><i>Background:</i></b> West Nile Virus (WNV) infection is endemic in Italy, but it has rarely reported in humans in Southern Italy. We report the first human outbreak of WNV infection in the Campania region, Italy. <b><i>Results:</i></b> Five confirmed and seven probable cases of WNV were identified from August to September 2024. Predominantly affecting elderly males with comorbidities, all but one patient developed West Nile neuroinvasive disease, presenting with fever and impaired consciousness. Remdesivir was administered off-label in four cases, potentially reducing hospitalization and improving outcomes. Mortality was limited to two cases, attributed to bacterial infections. <b><i>Conclusions:</i></b> The outbreak underscores the importance of heightened surveillance in Italy and raises the potential for remdesivir in WNV treatment.</p>\",\"PeriodicalId\":23683,\"journal\":{\"name\":\"Vector borne and zoonotic diseases\",\"volume\":\" \",\"pages\":\"565-567\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Vector borne and zoonotic diseases\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1177/15303667251360262\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/11 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Vector borne and zoonotic diseases","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/15303667251360262","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/11 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Outbreak of Human Neuroinvasive West Nile Virus Infection in Campania, Italy, August-September 2024.
Background: West Nile Virus (WNV) infection is endemic in Italy, but it has rarely reported in humans in Southern Italy. We report the first human outbreak of WNV infection in the Campania region, Italy. Results: Five confirmed and seven probable cases of WNV were identified from August to September 2024. Predominantly affecting elderly males with comorbidities, all but one patient developed West Nile neuroinvasive disease, presenting with fever and impaired consciousness. Remdesivir was administered off-label in four cases, potentially reducing hospitalization and improving outcomes. Mortality was limited to two cases, attributed to bacterial infections. Conclusions: The outbreak underscores the importance of heightened surveillance in Italy and raises the potential for remdesivir in WNV treatment.
期刊介绍：
Vector-Borne and Zoonotic Diseases is an authoritative, peer-reviewed journal providing basic and applied research on diseases transmitted to humans by invertebrate vectors or non-human vertebrates. The Journal examines geographic, seasonal, and other risk factors that influence the transmission, diagnosis, management, and prevention of this group of infectious diseases, and identifies global trends that have the potential to result in major epidemics.
Vector-Borne and Zoonotic Diseases coverage includes:
-Ecology
-Entomology
-Epidemiology
-Infectious diseases
-Microbiology
-Parasitology
-Pathology
-Public health
-Tropical medicine
-Wildlife biology
-Bacterial, rickettsial, viral, and parasitic zoonoses
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