卡斯尔曼病和相关疾病的形态谱:来自第22届欧洲血液病理学协会淋巴瘤研讨会的报告。

IF 3.1 3区 医学 Q1 PATHOLOGY
Gorana Gasljevic, Arturo Bonometti, Ioannis Anagnostopoulos, Olga Balaguè, Michiel Van den Brand, James R Cook, Camille Laurent, Maurilio Ponzoni, Leticia Quintanilla-Martinez, Birgitta Sander, Stefan Dirnhofer
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引用次数: 0

摘要

Castleman病(CD)是一种有趣而复杂的局部和全身性疾病,主要影响淋巴结,具有不同的表现和治疗需求。这些疾病是在克罗地亚杜布罗夫尼克举办的2024 EA4HP淋巴瘤研讨会第一届会议的主题。在本报告中,我们总结了85例提交的病例的特征,并回顾了所有CD亚型的鉴别诊断,陷阱和进展。具体来说,单中心CD的分子景观及其与滤泡树突状细胞增殖和惰性t淋巴细胞增殖的关系将被讨论。本文综述了特发性多中心性CD (MCD)、TAFRO综合征的频谱,以及POEMS-CD的临床和组织病理学特点。卡波西肉瘤相关疱疹病毒/人疱疹病毒8 (KSHV/HHV8) + MCD病例最为复杂,充分说明了KSHV/HHV8 +淋巴增生性疾病鉴别诊断的困难和重叠。最后,将讨论乳糜泻模拟物的重要主题,展示临床、实验室、组织病理学和分子数据的整合如何是确认乳糜泻诊断的必要条件,以及如何将乳糜泻与许多肿瘤性、自身免疫性和感染性模拟物区分开来。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The morphological spectrum of Castleman disease and related disorders: a report from the Lymphoma Workshop of the 22nd Meeting of the European Association of Hematopathology.

Castleman disease (CD) is an intriguing and complicated group of local and systemic disorders mainly affecting lymph nodes with heterogeneous presentation and therapeutic needs. These disorders were the topic of Session 1 of the Lymphoma Workshop at the 2024 EA4HP in Dubrovnik, Croatia. In this report, we summarize the features of the 85 submitted cases and review the differential diagnosis, pitfalls, and advances for all CD subtypes. Specifically, the molecular landscape of unicentric CD and its relationship with follicular dendritic cell proliferations and indolent T-lymphoblastic proliferation will be discussed. The spectrum of idiopathic multicentric CD (MCD), TAFRO syndrome, as well as the clinical and histopathological peculiarities of POEMS-CD, is reviewed. Cases of Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 (KSHV/HHV8) + MCD were the most complicated and well demonstrated the difficulties and overlaps in the differential diagnosis of KSHV/HHV8 + lymphoproliferative disorders. Finally, the important topic of CD mimickers will be addressed, demonstrating how the integration of clinical, laboratory, histopathological, and molecular data is mandatory to confirm a diagnosis of CD and how to distinguish it from the many neoplastic, autoimmune, and infective mimickers.

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来源期刊
Virchows Archiv
Virchows Archiv 医学-病理学
CiteScore
7.40
自引率
2.90%
发文量
204
审稿时长
4-8 weeks
期刊介绍: Manuscripts of original studies reinforcing the evidence base of modern diagnostic pathology, using immunocytochemical, molecular and ultrastructural techniques, will be welcomed. In addition, papers on critical evaluation of diagnostic criteria but also broadsheets and guidelines with a solid evidence base will be considered. Consideration will also be given to reports of work in other fields relevant to the understanding of human pathology as well as manuscripts on the application of new methods and techniques in pathology. Submission of purely experimental articles is discouraged but manuscripts on experimental work applicable to diagnostic pathology are welcomed. Biomarker studies are welcomed but need to abide by strict rules (e.g. REMARK) of adequate sample size and relevant marker choice. Single marker studies on limited patient series without validated application will as a rule not be considered. Case reports will only be considered when they provide substantial new information with an impact on understanding disease or diagnostic practice.
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