肺化疗灌注提高结直肠癌转移切除术后的无复发生存率。

IF 1.4 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS
Evgeny Levchenko, Mikhail Klochkov, Alexander Mikhnin, Nikita Levchenko, Stepan Ergnyan, Oleg Mamontov, Viktoriia Shabinskaya
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引用次数: 0

摘要

转移瘤切除术是一种被广泛推荐的结肠直肠癌肺转移手术。肺转移切除术的主要缺点是转移复发率高,几乎有一半的患者发生转移复发率。为了抑制残留的肺微灶,采用了孤立肺化学灌注(ILuP),但其有效性尚未得到研究。材料与方法:对160例肺转移瘤患者行肺转移瘤切除术的结果进行分析。主组65例患者行开放性转移性肺化疗灌注切除术;对照组95例患者行标准开腹或胸腔镜转移瘤切除术。研究设计采用最近邻法进行1:1伪随机化。对于17例因复发性肺转移而行标准转移切除术后再行ILuP转移切除术的患者,将这些患者本身作为最近的邻居。其余患者采用PSM方法选择匹配对。在平衡样本后,主要和对照组包括41对观察结果,根据Kaplan-Meier进行进一步分析,评估无复发肺生存期。采用Cox模型研究影响生存的因素。结果:主组患者的中位无复发生存期为22.3个月,而对照组为9.1个月。主组1年无复发生存率为77.5±6.6%,对照组为38.1±9.1%。结论:孤立肺化疗灌注可使结直肠癌肺转移切除术后的中位无复发生存期延长一年以上。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Lung Chemoperfusion Improves Relapse-Free Survival after Metastasectomy for Colorectal Cancer.

Metastasectomy is a recommended and widely used operation for pulmonary metastases from colorectal cancer (CRC). The main disadvantage of pulmonary metastasectomy is the high rate of metastasis recurrence, which occurs in almost half of patients. To suppress residual pulmonary microfoci, isolated lung chemoperfusion (ILuP) is used, but its effectiveness has not been studied.The results of pulmonary metastasectomy were studied in 160 patients. In 65 patients of the main group, open metastasectomy with isolated chemoperfusion of the lungs was performed; in 95 patients of the control group, standard open or thoracoscopic metastasectomy was performed. The study design included 1:1 pseudorandomization using the nearest neighbor method. For 17 patients who underwent standard metastasectomy and then metastasectomy with ILuP for recurrent pulmonary metastases, these patients themselves were used as the nearest neighbor. For the remaining patients, the matching pairs were selected by the Propensity Score Matching method. After balancing the sample, the main and control groups comprised 41 pairs of observations, which were subjected to further analysis with assessment of relapse-free pulmonary survival according to Kaplan-Meier. Factors influencing survival were studied in the Cox's model.The median recurrence-free survival in patients of the main group who underwent metastasectomy with ILuP was 22.3 months versus 9.1 months in the control group. One-year recurrence-free survival in the main group was 77.5 ±  6.6% versus 38.1 ± 9.1% in the control group.Isolated lung chemoperfusion increases median recurrence-free survival after pulmonary metastasectomy by more than one year for colorectal cancer.

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来源期刊
CiteScore
3.40
自引率
6.70%
发文量
365
审稿时长
3 months
期刊介绍: The Thoracic and Cardiovascular Surgeon publishes articles of the highest standard from internationally recognized thoracic and cardiovascular surgeons, cardiologists, anesthesiologists, physiologists, and pathologists. This journal is an essential resource for anyone working in this field. Original articles, short communications, reviews and important meeting announcements keep you abreast of key clinical advances, as well as providing the theoretical background of cardiovascular and thoracic surgery. Case reports are published in our Open Access companion journal The Thoracic and Cardiovascular Surgeon Reports.
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