基因型引导营养干预减少年轻人心脏代谢危险因素：随机对照试验的研究方案。

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-07-09 DOI:10.1016/j.clnesp.2025.07.008

Karina Rodrigues , Marcela M. Mendes , Lana Pacheco Franco-Gedda , Nara R. da Silva , Mariana Oliveira , Flávia C.F. Silva , Flávia Campos Corgosinho , Kristy Soraya Coelho , Franco Maria Lajolo , José M. Aldrighi , Carla M. Prado , Lu Qi , Karani Santhanakrishnan Vimaleswaran , Maria Aderuza Horst

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引用次数: 0

摘要

背景与目的：心血管代谢疾病（CMD），包括心血管疾病、肥胖和糖尿病，是受生活方式因素（如饮食）、维生素D状况和遗传易感性影响的主要公共卫生挑战。单核苷酸多态性（SNPs）有助于cmd相关性状（M-GRS）的遗传风险评分，最近的研究表明，基于基因型的营养干预有可能降低这些风险。本研究旨在评估基因型引导的营养干预与标准饮食建议在年轻人中的有效性。方法：这项为期12个月的研究包括6个月的干预期和6个月的自由生活期。将在基线、3个月、6个月和12个月收集数据。我们计划招募先前在巴西肥胖、生活方式和糖尿病（BOLD）研究中进行基因分型的年轻人（23-29岁），并根据34个snp按BMI、性别和M-GRS随机分组。对照组将遵循标准的巴西饮食，每天摄入1000国际单位的维生素D3。个性化干预组将接受基于M-GRS中snp基因-饮食相互作用的基因型指导饮食计划，以及基于其遗传缺乏风险（D-GRS）的个性化维生素D3补充（1000或4000 IU）。将评估身体组成、生化指标和代谢组学，以体脂率的降低为主要结果。讨论：本研究将通过评估基因型指导的CMD风险管理饮食建议，为精确营养做出贡献，潜在地展示遗传信息如何优化饮食干预，减少CMD负担，改善整体健康结果。试验注册：巴西临床试验注册中心：RBR-7b43sfr http://ensaiosclinicos.gov.br/rg/RBR-7b43sfr。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

A genotype-guided nutritional intervention to reduce cardiometabolic risk factors in young adults: Study protocol for a randomized controlled trial

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A genotype-guided nutritional intervention to reduce cardiometabolic risk factors in young adults: Study protocol for a randomized controlled trial

Background & aims

Cardiometabolic diseases (CMD), including cardiovascular disease, obesity and diabetes, are major public health challenges influenced by lifestyle factors (e.g., diet), vitamin D status, and genetic predisposition. Single nucleotide polymorphisms (SNPs) contribute to genetic risk scores for CMD-related traits (M-GRS) and recent research suggests that genotype-based nutritional interventions have the potential to reduce these risks. This study aims to evaluate the effectiveness of genotype-guided nutritional interventions versus standard dietary recommendations in young adults.

Methods

This 12-month study includes a 6-month intervention phase and a 6-month free-living phase. Data will be collected at baseline, 3, 6 and 12 months. We plan to recruit young adults (aged 23–29) previously genotyped from the Obesity, Lifestyle, and Diabetes in Brazil (BOLD) study and randomized by BMI, sex, and M-GRS based on 34 SNPs. The control group will follow a standard Brazilian diet with CMD-related recommendations and 1000 IU of vitamin D3 daily. The personalized intervention group will receive a genotype-guided dietary plan based on gene–diet interactions for SNPs in the M-GRS, along with personalized vitamin D3 supplementation (1000 or 4000 IU) based on their genetic risk for deficiency (D-GRS). Body composition, biochemical markers and metabolomics will be assessed, with the reduction in body fat percentage as the primary outcome.

Discussion

This study will contribute to precision nutrition by assessing genotype-guided dietary recommendations for CMD risk management, potentially demonstrating how genetic information can optimize dietary interventions and reduce CMD burdens, improving overall health outcomes.

Trial registration

Brazilian Registry of Clinical Trials: RBR-7b43sfr http://ensaiosclinicos.gov.br/rg/RBR-7b43sfr.

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.