衰老和神经系统疾病中的cGAS-STING通路：从机制到治疗

IF 4.4 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-07-09 DOI:10.1016/j.cellsig.2025.111978

Yi Li , Yonghao Chen , Yunlong Liu , Chunmiao Wang , Xiuping Fu , Mengtian Ren

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引用次数: 0

摘要

在人体众多的免疫信号转导通路中，环状GMP-AMP合成酶(cGAS)-干扰素基因刺激因子（STING）信号通路因其在细胞内感知DNA的关键作用而备受关注。本文综述了自噬功能障碍与线粒体功能障碍、慢性炎症与染色体不稳定、微核DNA形成等衰老现象与cGAS-STING通路的关系，以及cGAS-STING通路在与衰老相关的神经退行性疾病、神经系统感染、神经免疫疾病中的作用。最后，我们分析了特异性抑制cGAS-STING通路的药物的潜在治疗策略，如cGAS抑制剂、环GMP-AMP （cGAMP）抑制剂、STING抑制剂和线粒体保护剂。本文通过介绍各种疾病及其可能的治疗方案，深入分析cGAS-STING通路对衰老过程和神经系统疾病的影响，探讨其在衰老和神经系统疾病中的作用及其潜在的治疗前景。

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The cGAS-STING pathway in aging and neurological diseases: From mechanisms to treatment

Among the numerous immune signal transduction pathways in the human body, the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has attracted much attention due to its crucial role in sensing DNA within cells. In this article, we summarize the relationships between some phenomena of aging and the cGAS-STING pathway, including autophagy dysfunction and mitochondrial dysfunction, chronic inflammation and Chromosome instability and micronucleus DNA formation, and the roles of the cGAS-STING pathway in neurodegenerative diseases related to aging, neurological infections, and neuroimmune diseases. Finally, we analyze the potential therapeutic strategies of drugs that specifically inhibit the cGAS-STING pathway, such as cGAS inhibitors, Cyclic GMP-AMP (cGAMP) inhibitors, STING inhibitors and mitochondrial protectants. By introducing various diseases and their possible treatment options, this review deeply analyzes the impact of the cGAS-STING pathway on the aging process and neurological diseases, and explores its role in aging and neurological diseases as well as its potential therapeutic prospects.

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.