{"title":"深共晶溶剂介导的Pictet-Spengler反应及有氧氧化合成β-碳啉及其相关天然产物","authors":"Bhuvana Narasimman","doi":"10.1016/j.tgchem.2025.100082","DOIUrl":null,"url":null,"abstract":"<div><div>An eco-friendly, one-pot synthesis of <em>β</em>-carboline derivatives using deep eutectic solvent is reported. This protocol utilizes commercially available aldehydes and tryptamine, involving Pictet–Spengler cyclization followed by aerobic oxidation. This environmentally friendly methodology offers access to various <em>β</em>-carboline alkaloids Nitramarine, Nitraridine, Eudistomin U, Norharmane, Harmane, and their analogues in a single step with 30–68% yields.</div></div>","PeriodicalId":101215,"journal":{"name":"Tetrahedron Green Chem","volume":"6 ","pages":"Article 100082"},"PeriodicalIF":0.0000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Deep eutectic solvent mediated synthesis of β-carbolines and related natural products via Pictet–Spengler reaction and aerobic oxidation\",\"authors\":\"Bhuvana Narasimman\",\"doi\":\"10.1016/j.tgchem.2025.100082\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>An eco-friendly, one-pot synthesis of <em>β</em>-carboline derivatives using deep eutectic solvent is reported. This protocol utilizes commercially available aldehydes and tryptamine, involving Pictet–Spengler cyclization followed by aerobic oxidation. This environmentally friendly methodology offers access to various <em>β</em>-carboline alkaloids Nitramarine, Nitraridine, Eudistomin U, Norharmane, Harmane, and their analogues in a single step with 30–68% yields.</div></div>\",\"PeriodicalId\":101215,\"journal\":{\"name\":\"Tetrahedron Green Chem\",\"volume\":\"6 \",\"pages\":\"Article 100082\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Tetrahedron Green Chem\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2773223125000214\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Green Chem","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2773223125000214","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
报道了一种利用深共晶溶剂一锅法合成β-羰基衍生物的方法。该方案利用市售醛和色胺，包括Pictet-Spengler环化，然后进行有氧氧化。这种环境友好的方法可以在一个步骤中获得各种β-碳碱生物碱Nitramarine， Nitraridine, Eudistomin U, Norharmane， Harmane及其类似物，收率为30-68%。
Deep eutectic solvent mediated synthesis of β-carbolines and related natural products via Pictet–Spengler reaction and aerobic oxidation
An eco-friendly, one-pot synthesis of β-carboline derivatives using deep eutectic solvent is reported. This protocol utilizes commercially available aldehydes and tryptamine, involving Pictet–Spengler cyclization followed by aerobic oxidation. This environmentally friendly methodology offers access to various β-carboline alkaloids Nitramarine, Nitraridine, Eudistomin U, Norharmane, Harmane, and their analogues in a single step with 30–68% yields.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
