表观遗传因素对2型糖尿病的影响：对发展和发病机制的见解

Q2 Medicine

Obesity Medicine Pub Date : 2025-07-01 DOI:10.1016/j.obmed.2025.100635

Thammanna Gowda SS, Shobith Rangappa, Parimala Hanumesh

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引用次数: 0

摘要

《发展和发病机制》研究了表观遗传修饰，如DNA甲基化、组蛋白改变和非编码RNA，在2型糖尿病（T2D）的发生和进展中的关键作用。它强调了环境因素、生活方式选择和遗传倾向如何影响这些表观遗传变化，促进胰岛素抵抗、β细胞功能障碍和其他T2D的关键机制。这篇综述提供了对糖尿病发病中遗传和表观遗传因素之间复杂相互作用的全面理解。目的探讨表观遗传修饰在2型糖尿病（T2D）发生和发病中的作用。它研究了环境因素、生活方式和遗传易感性如何影响表观遗传变化，促进胰岛素抵抗和β细胞功能障碍等关键机制。通过提供这些相互作用的见解，该综述旨在加强对T2D病因的理解，并为潜在的治疗策略提供信息。结果研究表明，表观遗传修饰，包括DNA甲基化、组蛋白改变和非编码RNA调控，在2型糖尿病（T2D）的发生和进展中起着重要作用。它强调了环境因素、生活方式选择和遗传易感性如何导致这些表观遗传标记的变化，从而驱动胰岛素抵抗、β细胞功能受损和T2D的其他方面。这些发现强调了针对表观遗传途径的治疗T2D的新方法的潜力。结论表观遗传因素在2型糖尿病的发生发展中起着至关重要的作用，为治疗干预提供了有希望的靶点。了解这些机制可能会导致更有效的预防和治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

The impact of epigenetic factors in type 2 diabetes: Insights into development and pathogenesis

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The impact of epigenetic factors in type 2 diabetes: Insights into development and pathogenesis

Background

Insights into Development and Pathogenesis investigates the critical role of epigenetic modifications, such as DNA methylation, histone alterations, and non-coding RNA, in the onset and progression of Type 2 diabetes (T2D). It highlights how environmental factors, lifestyle choices, and genetic predispositions influence these epigenetic changes, contributing to insulin resistance, beta-cell dysfunction, and other key mechanisms of T2D. The review provides a comprehensive understanding of the complex interplay between genetic and epigenetic factors in diabetes pathogenesis.

Aim

The aim of this review is to explore the role of epigenetic modifications in the development and pathogenesis of Type 2 diabetes (T2D). It examines how environmental factors, lifestyle, and genetic predisposition influence epigenetic changes, contributing to key mechanisms such as insulin resistance and beta-cell dysfunction. By providing insights into these interactions, the review aims to enhance understanding of T2D etiology and inform potential therapeutic strategies.

Result

The review reveals that epigenetic modifications, including DNA methylation, histone alterations, and non-coding RNA regulation, significantly contribute to the development and progression of Type 2 diabetes (T2D). It highlights how environmental factors, lifestyle choices, and genetic predisposition lead to changes in these epigenetic marks, driving insulin resistance, impaired beta-cell function, and other aspects of T2D. The findings underscore the potential of targeting epigenetic pathways for novel therapeutic approaches in managing T2D.

Conclusion

The review concludes that epigenetic factors play a crucial role in Type 2 diabetes development, offering promising targets for therapeutic intervention. Understanding these mechanisms may lead to more effective prevention and treatment strategies.

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.