衰老、炎症和免疫系统之间的相互作用

IF 7.7 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2025-07-11 DOI:10.1101/gad.353125.125

Jesús Gil

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引用次数: 0

摘要

在过去的40年里，老龄化研究取得了重大进展。虽然衰老曾经被认为是一个随机过程，但现在人们认为它是由可以用现代细胞和分子生物学方法解剖的途径和过程调节的。经历细胞衰老的细胞的异常积累和慢性无菌炎症的增加是衰老的两个标志。在这里，我们讨论这些过程是如何连接的，以及衰老细胞和免疫系统之间的关系如何决定炎症过程对年龄相关功能障碍和疾病的影响程度。

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The interplay between senescence, inflammation, and the immune system

The past 40 years have witnessed significant progress in aging research. Although aging was once considered a stochastic process, it is now understood to be regulated by pathways and processes that can be dissected with modern cellular and molecular biology approaches. The aberrant accumulation of cells undergoing cellular senescence and an increase in chronic, sterile inflammation are two of those aging hallmarks. Here we discuss how these processes are connected and how the relationship between senescent cells and the immune system dictates the extent of inflammatory processes contributing to age-related dysfunction and disease.

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).