秀丽隐杆线虫的认知能力随着年龄的增长而下降：不仅仅是向前和向后摆动

IF 7.7 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2025-07-11 DOI:10.1101/gad.353115.125

Titas Sengupta, Coleen T. Murphy

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引用次数: 0

摘要

在过去的30年里，秀丽隐杆线虫一直处于与年龄相关的衰退机制研究的前沿。尽管秀丽隐杆线虫在长寿研究中很受欢迎，但它在研究复杂行为和这些功能随着年龄的增长而逐渐下降方面的潜力却没有得到充分的重视。通过对学习和记忆的分析，我们已经确定了调节这些行为的遗传途径，并确定了蠕虫和小鼠随着年龄增长而增强这些功能的新机制。由于秀丽隐杆线虫是如此高度保守，这些最近描述的机制中的一些可能是防止人类认知能力随着年龄增长而下降的良好目标。

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C. elegans cognitive decline with age: more than just wiggling forward and backward

Caenorhabditis elegans has been at the forefront of research on mechanisms of age-related decline for the past 30 years. Despite its popularity in longevity research, C. elegans is underappreciated for its potential to study complex behaviors and the progressive decline in these functions with age. Using assays of learning and memory, we have identified genetic pathways that regulate these behaviors and identified new mechanisms to boost these functions with age in both worms and mice. Because C. elegans is so highly conserved, some of these recently described mechanisms may be good targets to prevent human cognitive decline with age.

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来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).