超越通常的怀疑：将衰老研究从经典模型扩展到非常酷的动物

IF 7.7 1区生物学 Q1 CELL BIOLOGY

Genes & development Pub Date : 2025-07-11 DOI:10.1101/gad.353124.125

Amy Walker

{"title":"超越通常的怀疑：将衰老研究从经典模型扩展到非常酷的动物","authors":"Amy Walker","doi":"10.1101/gad.353124.125","DOIUrl":null,"url":null,"abstract":"Model organisms such as yeast, worms, flies, and mice were key to discovering genes and other factors controlling life span and directly improved our understanding of human aging. Today, genomic tools allow study of a broader range of species, including those with short or long life spans, closely related species with different aging rates, or differences in interspecies aging. Models such as killifish, bats, and ants have much to teach us about human aging. They also reveal a flexible biological toolkit that species can use when evolutionary pressures drive rebalancing of growth, reproduction, or resilience with age-related decline.","PeriodicalId":12591,"journal":{"name":"Genes & development","volume":"12 1","pages":""},"PeriodicalIF":7.7000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Beyond the usual suspects: expanding aging research from classic models to really cool critters\",\"authors\":\"Amy Walker\",\"doi\":\"10.1101/gad.353124.125\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Model organisms such as yeast, worms, flies, and mice were key to discovering genes and other factors controlling life span and directly improved our understanding of human aging. Today, genomic tools allow study of a broader range of species, including those with short or long life spans, closely related species with different aging rates, or differences in interspecies aging. Models such as killifish, bats, and ants have much to teach us about human aging. They also reveal a flexible biological toolkit that species can use when evolutionary pressures drive rebalancing of growth, reproduction, or resilience with age-related decline.\",\"PeriodicalId\":12591,\"journal\":{\"name\":\"Genes & development\",\"volume\":\"12 1\",\"pages\":\"\"},\"PeriodicalIF\":7.7000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Genes & development\",\"FirstCategoryId\":\"99\",\"ListUrlMain\":\"https://doi.org/10.1101/gad.353124.125\",\"RegionNum\":1,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genes & development","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1101/gad.353124.125","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

酵母菌、蠕虫、苍蝇和老鼠等模式生物是发现控制寿命的基因和其他因素的关键，并直接提高了我们对人类衰老的理解。今天，基因组工具允许研究更广泛的物种，包括那些寿命短或长的物种，衰老速度不同的近亲物种，或物种间衰老的差异。像鳉鱼、蝙蝠和蚂蚁这样的模型可以教会我们很多关于人类衰老的知识。它们还揭示了一个灵活的生物工具包，当进化压力推动生长、繁殖或适应力与年龄相关的衰退重新平衡时，物种可以使用它。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Beyond the usual suspects: expanding aging research from classic models to really cool critters

Model organisms such as yeast, worms, flies, and mice were key to discovering genes and other factors controlling life span and directly improved our understanding of human aging. Today, genomic tools allow study of a broader range of species, including those with short or long life spans, closely related species with different aging rates, or differences in interspecies aging. Models such as killifish, bats, and ants have much to teach us about human aging. They also reveal a flexible biological toolkit that species can use when evolutionary pressures drive rebalancing of growth, reproduction, or resilience with age-related decline.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Genes & development 生物-发育生物学

CiteScore

17.50

自引率

1.90%

发文量

审稿时长

3-6 weeks

期刊介绍： Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).