减轻糖尿病性心肌病:多药联合调节大鼠模型中ICAM-1、VCAM-1和NF-κB表达的治疗潜力

Prabhnain Kaur, Ritu, Kalicharan Sharma, Ramesh Kumar Goyal
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引用次数: 0

摘要

背景:糖尿病性心肌病(DCM)仍然是一个重要的健康问题,需要创新的治疗方法。本研究探讨了多草药组合(PHC)在缓解DCM方面的潜力,并深入研究了潜在的分子机制。方法:采用中药复方给药治疗糖尿病和心肌病大鼠模型。分子分析包括心脏组织中ICAM-1、VCAM-1和NF- κB的表达。对心脏健康进行组织病理学和功能评估。结果:中药治疗组血糖水平显著降低,心功能改善,射血分数和心输出量增加。心脏损伤标志物CK-MB和hs-CRP分别显著降低66.6%和50%。血脂改善包括总胆固醇和甘油三酯分别降低28.5%和31.1%。TGF-β水平明显降低,提示抗纤维化作用。此外,NF-κB、ICAM-1和VCAM-1的表达显著下调,证实了复方的抗炎潜力。这些发现强调了其心脏保护作用,使其成为减轻糖尿病性心肌病的有希望的治疗方法。结论:该研究揭示了一种有希望的DCM治疗策略,其特点是PHC能够调节ICAM-1、VCAM-1和NF-κB的表达。这一分子洞察强调了DCM管理创新干预的潜力,并为改善糖尿病患者的心脏健康提供了希望。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Mitigating Diabetic Cardiomyopathy: The Therapeutic Potential of a Poly Herbal Combination in Modulating ICAM-1, VCAM-1, and NF-κB Expression in Rat Model.

Background: Diabetic Cardiomyopathy (DCM) remains a significant health concern, necessitating innovative therapeutic approaches. This study explores the potential of a polyherbal combination (PHC) in mitigating DCM and delves into the underlying molecular mechanisms.

Methods: Rat models with induced diabetes and cardiomyopathy were administered the polyherbal combination. Molecular analyses included the assessment of ICAM-1, VCAM-1, and NF- κB expression in cardiac tissue. Histopathological and functional evaluations of cardiac health were performed.

Results: The polyherbal-treated group showed a significant reduction in blood glucose levels and improved cardiac function, as indicated by increased ejection fraction and cardiac output. Cardiac injury markers, CK-MB and hs-CRP, were significantly reduced by 66.6% and 50% respectively. Lipid profile improvements included lower total cholesterol and triglycerides by 28.5% and 31.1%, respectively. TGF-β levels were markedly reduced, suggesting an anti-fibrotic effect. Additionally, NF-κB, ICAM-1, and VCAM-1 expression were significantly downregulated, confirming the polyherbal formulation's anti-inflammatory potential. These findings highlight its cardioprotective effects, making it a promising therapeutic approach for mitigating diabetic cardiomyopathy.

Conclusion: The study unveils a promising therapeutic strategy for DCM, characterized by the PHC's ability to modulate ICAM-1, VCAM-1, and NF-κB expression. This molecular insight underscores the potential for innovative interventions in managing DCM and offers hope for improved cardiac health in individuals with diabetes.

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