{"title":"终止密码子上下文通过翻译终止动力学调节NMD效率。","authors":"Dasa Longman, Laura Monaghan, Javier F Cáceres","doi":"10.1016/j.xgen.2025.100948","DOIUrl":null,"url":null,"abstract":"<p><p>Nonsense-mediated mRNA decay efficiency varies unpredictably across transcripts containing premature termination codons. A new study by Kolakada et al.<sup>1</sup> demonstrates that glycine residues preceding stop codons create an extended translation termination window that enhances NMD activity, offering new mechanistic explanations for NMD variability and improved clinical variant interpretation.</p>","PeriodicalId":72539,"journal":{"name":"Cell genomics","volume":"5 7","pages":"100948"},"PeriodicalIF":11.1000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278622/pdf/","citationCount":"0","resultStr":"{\"title\":\"Stop codon context modulates NMD efficiency through translation termination kinetics.\",\"authors\":\"Dasa Longman, Laura Monaghan, Javier F Cáceres\",\"doi\":\"10.1016/j.xgen.2025.100948\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Nonsense-mediated mRNA decay efficiency varies unpredictably across transcripts containing premature termination codons. A new study by Kolakada et al.<sup>1</sup> demonstrates that glycine residues preceding stop codons create an extended translation termination window that enhances NMD activity, offering new mechanistic explanations for NMD variability and improved clinical variant interpretation.</p>\",\"PeriodicalId\":72539,\"journal\":{\"name\":\"Cell genomics\",\"volume\":\"5 7\",\"pages\":\"100948\"},\"PeriodicalIF\":11.1000,\"publicationDate\":\"2025-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278622/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell genomics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.xgen.2025.100948\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell genomics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.xgen.2025.100948","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Stop codon context modulates NMD efficiency through translation termination kinetics.
Nonsense-mediated mRNA decay efficiency varies unpredictably across transcripts containing premature termination codons. A new study by Kolakada et al.1 demonstrates that glycine residues preceding stop codons create an extended translation termination window that enhances NMD activity, offering new mechanistic explanations for NMD variability and improved clinical variant interpretation.
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