{"title":"外周染色质重塑在合子基因组激活的中心。","authors":"Laure de Chancel, Jean-Léon Maître","doi":"10.1016/j.xgen.2025.100922","DOIUrl":null,"url":null,"abstract":"<p><p>Pal and colleagues<sup>1</sup> investigate the molecular regulation of LAD establishment in mouse preimplantation embryos. This study provides insights into the physiological remodeling of LADs, revealing that zygotic LADs may be, in fact, dispensable during the very early steps of mouse development when they can be rescued at the 2-cell stage.</p>","PeriodicalId":72539,"journal":{"name":"Cell genomics","volume":"5 7","pages":"100922"},"PeriodicalIF":11.1000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278610/pdf/","citationCount":"0","resultStr":"{\"title\":\"Peripheral chromatin remodeling at the center of zygotic genome activation.\",\"authors\":\"Laure de Chancel, Jean-Léon Maître\",\"doi\":\"10.1016/j.xgen.2025.100922\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Pal and colleagues<sup>1</sup> investigate the molecular regulation of LAD establishment in mouse preimplantation embryos. This study provides insights into the physiological remodeling of LADs, revealing that zygotic LADs may be, in fact, dispensable during the very early steps of mouse development when they can be rescued at the 2-cell stage.</p>\",\"PeriodicalId\":72539,\"journal\":{\"name\":\"Cell genomics\",\"volume\":\"5 7\",\"pages\":\"100922\"},\"PeriodicalIF\":11.1000,\"publicationDate\":\"2025-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278610/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cell genomics\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.xgen.2025.100922\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell genomics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.xgen.2025.100922","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
Peripheral chromatin remodeling at the center of zygotic genome activation.
Pal and colleagues1 investigate the molecular regulation of LAD establishment in mouse preimplantation embryos. This study provides insights into the physiological remodeling of LADs, revealing that zygotic LADs may be, in fact, dispensable during the very early steps of mouse development when they can be rescued at the 2-cell stage.
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