{"title":"18F-FDG和18F-PSMA-1007 PET/CT对前列腺癌骨转移的诊断价值：回顾性比较分析。","authors":"Qingyun Wang, Lingmei Wu, Fengxiao Gao","doi":"10.56434/j.arch.esp.urol.20257805.77","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The early and accurate diagnosis of prostate cancer (PCa) bone metastases is of great importance for formulating the best treatment plan and improving the prognosis of patients. This work aimed to compare and analyse the application value of <sup>18</sup>F-fludeoxyglucose (FDG) and <sup>18</sup>F-prostate-specific membrane antigen-1007 (<sup>18</sup>F-PSMA-1007) positron emission tomography/computed tomography (PET/CT) in the diagnosis of PCa bone metastases.</p><p><strong>Methods: </strong>Data from the pathological specimens from patients diagnosed with PCa admitted to the Xingtai People's Hospital from October 2021 to October 2024 were retrospectively collected. These patients underwent <sup>18</sup>F-FDG PET/CT and <sup>18</sup>F-PSMA-1007 PET/CT scans, with an interval not exceeding 3 days between the two examinations. The sensitivity, specificity, negative and positive predictive values and diagnostic coincidence rate of the two imaging methods were evaluated by comparing the lesion count and anatomical distribution of prostatic bone metastases after the two examinations. The pathological diagnosis results of prostate lesion needle biopsy or radical PCa resection specimens were taken as the gold standard.</p><p><strong>Results: </strong>Seventy-eight patients with PCa were admitted during the study. A total of 418 positive lesions, 78 primary prostatic lesions, 340 bone metastases and 12 negative lesions were detected by prostate lesion biopsy as the gold standard. A total of 410 positive foci were found in <sup>18</sup>F-PSMA-1007, including 78 primary prostatic foci and 332 bone metastases. A total of 376 positive lesions, 76 prostate lesions and 300 bone metastases were found in <sup>18</sup>F-FDG. <sup>18</sup>F-PSMA-1007 detected more PCa bone metastases in different bone regions than <sup>18</sup>F-FDG, but the difference was not statistically significant (<i>p</i> > 0.05). The sensitivity, specificity, positive and negative predictive values and diagnostic coincidence rate of <sup>18</sup>F-PSMA-1007 were significantly higher than those of <sup>18</sup>F-FDG (<i>p</i> < 0.01).</p><p><strong>Conclusions: </strong><sup>18</sup>F-PSMA-1007 PET/CT has high sensitivity and diagnostic coincidence rate and is expected to become a new standard for the diagnosis of PCa bone metastases.</p>","PeriodicalId":48852,"journal":{"name":"Archivos Espanoles De Urologia","volume":"78 5","pages":"572-578"},"PeriodicalIF":0.9000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Diagnostic Value of <sup>18</sup>F-FDG and <sup>18</sup>F-PSMA-1007 PET/CT in Bone Metastases from Prostate Cancer: Retrospective Comparative Analysis.\",\"authors\":\"Qingyun Wang, Lingmei Wu, Fengxiao Gao\",\"doi\":\"10.56434/j.arch.esp.urol.20257805.77\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The early and accurate diagnosis of prostate cancer (PCa) bone metastases is of great importance for formulating the best treatment plan and improving the prognosis of patients. This work aimed to compare and analyse the application value of <sup>18</sup>F-fludeoxyglucose (FDG) and <sup>18</sup>F-prostate-specific membrane antigen-1007 (<sup>18</sup>F-PSMA-1007) positron emission tomography/computed tomography (PET/CT) in the diagnosis of PCa bone metastases.</p><p><strong>Methods: </strong>Data from the pathological specimens from patients diagnosed with PCa admitted to the Xingtai People's Hospital from October 2021 to October 2024 were retrospectively collected. These patients underwent <sup>18</sup>F-FDG PET/CT and <sup>18</sup>F-PSMA-1007 PET/CT scans, with an interval not exceeding 3 days between the two examinations. The sensitivity, specificity, negative and positive predictive values and diagnostic coincidence rate of the two imaging methods were evaluated by comparing the lesion count and anatomical distribution of prostatic bone metastases after the two examinations. The pathological diagnosis results of prostate lesion needle biopsy or radical PCa resection specimens were taken as the gold standard.</p><p><strong>Results: </strong>Seventy-eight patients with PCa were admitted during the study. A total of 418 positive lesions, 78 primary prostatic lesions, 340 bone metastases and 12 negative lesions were detected by prostate lesion biopsy as the gold standard. A total of 410 positive foci were found in <sup>18</sup>F-PSMA-1007, including 78 primary prostatic foci and 332 bone metastases. A total of 376 positive lesions, 76 prostate lesions and 300 bone metastases were found in <sup>18</sup>F-FDG. <sup>18</sup>F-PSMA-1007 detected more PCa bone metastases in different bone regions than <sup>18</sup>F-FDG, but the difference was not statistically significant (<i>p</i> > 0.05). The sensitivity, specificity, positive and negative predictive values and diagnostic coincidence rate of <sup>18</sup>F-PSMA-1007 were significantly higher than those of <sup>18</sup>F-FDG (<i>p</i> < 0.01).</p><p><strong>Conclusions: </strong><sup>18</sup>F-PSMA-1007 PET/CT has high sensitivity and diagnostic coincidence rate and is expected to become a new standard for the diagnosis of PCa bone metastases.</p>\",\"PeriodicalId\":48852,\"journal\":{\"name\":\"Archivos Espanoles De Urologia\",\"volume\":\"78 5\",\"pages\":\"572-578\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2025-06-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Archivos Espanoles De Urologia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.56434/j.arch.esp.urol.20257805.77\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archivos Espanoles De Urologia","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.56434/j.arch.esp.urol.20257805.77","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
Diagnostic Value of 18F-FDG and 18F-PSMA-1007 PET/CT in Bone Metastases from Prostate Cancer: Retrospective Comparative Analysis.
Objective: The early and accurate diagnosis of prostate cancer (PCa) bone metastases is of great importance for formulating the best treatment plan and improving the prognosis of patients. This work aimed to compare and analyse the application value of 18F-fludeoxyglucose (FDG) and 18F-prostate-specific membrane antigen-1007 (18F-PSMA-1007) positron emission tomography/computed tomography (PET/CT) in the diagnosis of PCa bone metastases.
Methods: Data from the pathological specimens from patients diagnosed with PCa admitted to the Xingtai People's Hospital from October 2021 to October 2024 were retrospectively collected. These patients underwent 18F-FDG PET/CT and 18F-PSMA-1007 PET/CT scans, with an interval not exceeding 3 days between the two examinations. The sensitivity, specificity, negative and positive predictive values and diagnostic coincidence rate of the two imaging methods were evaluated by comparing the lesion count and anatomical distribution of prostatic bone metastases after the two examinations. The pathological diagnosis results of prostate lesion needle biopsy or radical PCa resection specimens were taken as the gold standard.
Results: Seventy-eight patients with PCa were admitted during the study. A total of 418 positive lesions, 78 primary prostatic lesions, 340 bone metastases and 12 negative lesions were detected by prostate lesion biopsy as the gold standard. A total of 410 positive foci were found in 18F-PSMA-1007, including 78 primary prostatic foci and 332 bone metastases. A total of 376 positive lesions, 76 prostate lesions and 300 bone metastases were found in 18F-FDG. 18F-PSMA-1007 detected more PCa bone metastases in different bone regions than 18F-FDG, but the difference was not statistically significant (p > 0.05). The sensitivity, specificity, positive and negative predictive values and diagnostic coincidence rate of 18F-PSMA-1007 were significantly higher than those of 18F-FDG (p < 0.01).
Conclusions: 18F-PSMA-1007 PET/CT has high sensitivity and diagnostic coincidence rate and is expected to become a new standard for the diagnosis of PCa bone metastases.
期刊介绍：
Archivos Españoles de Urología published since 1944, is an international peer review, susbscription Journal on Urology with original and review articles on different subjets in Urology: oncology, endourology, laparoscopic, andrology, lithiasis, pediatrics , urodynamics,... Case Report are also admitted.
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