Yue Xiong, Tingting Wu, Lei Wang, Xinyi Shen, Yufeng Yin, Jian Wu, Tian Ren, Jing Cao, Tao Cheng, Mingjun Wang
{"title":"非典型抗磷脂综合征非标准抗磷脂抗体的临床意义。","authors":"Yue Xiong, Tingting Wu, Lei Wang, Xinyi Shen, Yufeng Yin, Jian Wu, Tian Ren, Jing Cao, Tao Cheng, Mingjun Wang","doi":"10.1093/mr/roaf060","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To analyse the correlation between non-criteria antiphospholipid antibodies (non-criteria aPLs) and clinical symptoms (recurrent miscarriage) in patients with seronegative antiphospholipid syndrome (SNAPS).Methods:Ninety-four SNAPS patients who were treated in the First Affiliated Hospital of Soochow University from May 2022 to May 2024 were included. Chemiluminescence immunoassay was used to detect anti-β2 glycoprotein I antibody (aβ2GPI), anti-cardiolipin antibody (aCL), and lupus anticoagulant. ELISA was used to detect the levels of anti-annexin A5 (ANXA5), anti-phosphatidylethanolamine antibody (aPE), anti-prothrombin IgG antibody (aPT IgG), anti-prothrombin IgM antibody (aPT IgM), anti-phosphatidylserine/prothrombin IgG antibody (aPS/PT IgG), and anti-phosphatidylserine/prothrombin IgM antibody (aPS/PT IgM). The correlation between non-criteria antiphospholipid antibodies and clinical events was analysed.</p><p><strong>Results: </strong>Compared with the non-criteria antibody-negative group, the positive group had a higher rate of positive antinuclear antibodies (p < 0.05). The proportion of recurrent miscarriage in the positive non-criteria antibody group was significantly higher than in the negative group (p = 0.002). Compared with the negative group, patients with positive anti-annexin A5 antibody and aPT IgM were more likely to have recurrent miscarriage (p < 0.05). Compared with the aPE-negative group, those with aPE-positive were more likely to experience early miscarriage (p = 0.039). Both aPT IgM subtype (p = 0.004) and ANXA5 (p = 0.013) antibodies were the risk factors for recurrent miscarriage. Patients with positive ANXA5, aPT IgG, and aPT/PS IgM antibodies showed a significant decrease in antibody titers after treatment (p < 0.05).</p><p><strong>Conclusion: </strong>Detection of non-criteria aPLs contributes to improving the diagnosis of SNAPS, assessing its development trends, and intervening promptly to prevent recurrent miscarriage.</p>","PeriodicalId":18705,"journal":{"name":"Modern Rheumatology","volume":" ","pages":""},"PeriodicalIF":1.9000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Clinical Significance of Non-Criteria Antiphospholipid Antibodies in Atypical Antiphospholipid Syndrome.\",\"authors\":\"Yue Xiong, Tingting Wu, Lei Wang, Xinyi Shen, Yufeng Yin, Jian Wu, Tian Ren, Jing Cao, Tao Cheng, Mingjun Wang\",\"doi\":\"10.1093/mr/roaf060\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To analyse the correlation between non-criteria antiphospholipid antibodies (non-criteria aPLs) and clinical symptoms (recurrent miscarriage) in patients with seronegative antiphospholipid syndrome (SNAPS).Methods:Ninety-four SNAPS patients who were treated in the First Affiliated Hospital of Soochow University from May 2022 to May 2024 were included. Chemiluminescence immunoassay was used to detect anti-β2 glycoprotein I antibody (aβ2GPI), anti-cardiolipin antibody (aCL), and lupus anticoagulant. ELISA was used to detect the levels of anti-annexin A5 (ANXA5), anti-phosphatidylethanolamine antibody (aPE), anti-prothrombin IgG antibody (aPT IgG), anti-prothrombin IgM antibody (aPT IgM), anti-phosphatidylserine/prothrombin IgG antibody (aPS/PT IgG), and anti-phosphatidylserine/prothrombin IgM antibody (aPS/PT IgM). The correlation between non-criteria antiphospholipid antibodies and clinical events was analysed.</p><p><strong>Results: </strong>Compared with the non-criteria antibody-negative group, the positive group had a higher rate of positive antinuclear antibodies (p < 0.05). The proportion of recurrent miscarriage in the positive non-criteria antibody group was significantly higher than in the negative group (p = 0.002). Compared with the negative group, patients with positive anti-annexin A5 antibody and aPT IgM were more likely to have recurrent miscarriage (p < 0.05). Compared with the aPE-negative group, those with aPE-positive were more likely to experience early miscarriage (p = 0.039). Both aPT IgM subtype (p = 0.004) and ANXA5 (p = 0.013) antibodies were the risk factors for recurrent miscarriage. Patients with positive ANXA5, aPT IgG, and aPT/PS IgM antibodies showed a significant decrease in antibody titers after treatment (p < 0.05).</p><p><strong>Conclusion: </strong>Detection of non-criteria aPLs contributes to improving the diagnosis of SNAPS, assessing its development trends, and intervening promptly to prevent recurrent miscarriage.</p>\",\"PeriodicalId\":18705,\"journal\":{\"name\":\"Modern Rheumatology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Modern Rheumatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1093/mr/roaf060\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"RHEUMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Modern Rheumatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1093/mr/roaf060","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
The Clinical Significance of Non-Criteria Antiphospholipid Antibodies in Atypical Antiphospholipid Syndrome.
Objective: To analyse the correlation between non-criteria antiphospholipid antibodies (non-criteria aPLs) and clinical symptoms (recurrent miscarriage) in patients with seronegative antiphospholipid syndrome (SNAPS).Methods:Ninety-four SNAPS patients who were treated in the First Affiliated Hospital of Soochow University from May 2022 to May 2024 were included. Chemiluminescence immunoassay was used to detect anti-β2 glycoprotein I antibody (aβ2GPI), anti-cardiolipin antibody (aCL), and lupus anticoagulant. ELISA was used to detect the levels of anti-annexin A5 (ANXA5), anti-phosphatidylethanolamine antibody (aPE), anti-prothrombin IgG antibody (aPT IgG), anti-prothrombin IgM antibody (aPT IgM), anti-phosphatidylserine/prothrombin IgG antibody (aPS/PT IgG), and anti-phosphatidylserine/prothrombin IgM antibody (aPS/PT IgM). The correlation between non-criteria antiphospholipid antibodies and clinical events was analysed.
Results: Compared with the non-criteria antibody-negative group, the positive group had a higher rate of positive antinuclear antibodies (p < 0.05). The proportion of recurrent miscarriage in the positive non-criteria antibody group was significantly higher than in the negative group (p = 0.002). Compared with the negative group, patients with positive anti-annexin A5 antibody and aPT IgM were more likely to have recurrent miscarriage (p < 0.05). Compared with the aPE-negative group, those with aPE-positive were more likely to experience early miscarriage (p = 0.039). Both aPT IgM subtype (p = 0.004) and ANXA5 (p = 0.013) antibodies were the risk factors for recurrent miscarriage. Patients with positive ANXA5, aPT IgG, and aPT/PS IgM antibodies showed a significant decrease in antibody titers after treatment (p < 0.05).
Conclusion: Detection of non-criteria aPLs contributes to improving the diagnosis of SNAPS, assessing its development trends, and intervening promptly to prevent recurrent miscarriage.
期刊介绍：
Modern Rheumatology publishes original papers in English on research pertinent to rheumatology and associated areas such as pathology, physiology, clinical immunology, microbiology, biochemistry, experimental animal models, pharmacology, and orthopedic surgery.
Occasional reviews of topics which may be of wide interest to the readership will be accepted. In addition, concise papers of special scientific importance that represent definitive and original studies will be considered.
Modern Rheumatology is currently indexed in Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, Academic OneFile, Current Abstracts, Elsevier Biobase, Gale, Health Reference Center Academic, OCLC, SCImago, Summon by Serial Solutions
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