David T. Rubin, Alison Potts Bleakman, Simon Travis, Marla Dubinsky, Stefan Schreiber, Remo Panaccione, Theresa Hunter Gibble, Cem Kayhan, Tommaso Panni, Eoin Flynn, Angelo D. Favia, Christian Atkinson, Sonal Saxena, Toshifumi Hibi
{"title":"肠急症对溃疡性结肠炎和克罗恩病的广泛影响：来自IBD经验交流需求和特征（CONFIDE）调查的美国、欧洲和日本患者和医疗保健专业人士的观点","authors":"David T. Rubin, Alison Potts Bleakman, Simon Travis, Marla Dubinsky, Stefan Schreiber, Remo Panaccione, Theresa Hunter Gibble, Cem Kayhan, Tommaso Panni, Eoin Flynn, Angelo D. Favia, Christian Atkinson, Sonal Saxena, Toshifumi Hibi","doi":"10.1007/s12325-025-03296-3","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Bowel urgency affects the quality of life of patients with Crohn’s disease (CD) and ulcerative colitis (UC). This study used data from the Communicating Needs and Features of IBD Experiences (CONFIDE) survey to explore patient and healthcare professional (HCP) perceptions on the broad impacts of bowel urgency on patients’ emotions and daily lives.</p><h3>Methods</h3><p>Online, quantitative, cross-sectional surveys were conducted among patients with moderate-to-severe UC or CD (defined based on previous treatment, steroid use, and/or hospitalization) and HCPs specialized in gastroenterology in Europe (France, Germany, Italy, Spain, UK), United States (US), and Japan. Data were summarized using descriptive statistics.</p><h3>Results</h3><p>The analysis included 200 US, 556 European, and 124 Japanese patients with UC and 215 US, 547 European, and 99 Japanese patients with CD; and 200 US, 503 European, and 100 Japanese HCPs. Patients experiencing bowel urgency in the past month and HCPs reported high emotional (up to: 97% patients, 97% HCPs) and daily life (up to: 85% patients, 97% HCPs) impacts due to bowel urgency in the US, Europe, and Japan. In all geographies, these impacts were similar among patients with UC and CD. Although patients and HCPs reported a broad impact of bowel urgency, HCPs perceived a higher impact than patients, but it was not among the top three most impactful symptoms on HCPs’ treatment decisions.</p><h3>Conclusions</h3><p>Bowel urgency affects the emotions and daily life of patients with UC or CD in the US, Europe, and Japan. A multidisciplinary approach is required to enhance care and develop suitable treatment strategies.</p></div>","PeriodicalId":7482,"journal":{"name":"Advances in Therapy","volume":"42 9","pages":"4510 - 4526"},"PeriodicalIF":4.0000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1007/s12325-025-03296-3.pdf","citationCount":"0","resultStr":"{\"title\":\"Broad Impact of Bowel Urgency in Ulcerative Colitis and Crohn’s Disease: US, European, and Japanese Patient and Healthcare Professional Perspectives from the Communicating Needs and Features of IBD Experiences (CONFIDE) Survey\",\"authors\":\"David T. Rubin, Alison Potts Bleakman, Simon Travis, Marla Dubinsky, Stefan Schreiber, Remo Panaccione, Theresa Hunter Gibble, Cem Kayhan, Tommaso Panni, Eoin Flynn, Angelo D. Favia, Christian Atkinson, Sonal Saxena, Toshifumi Hibi\",\"doi\":\"10.1007/s12325-025-03296-3\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Introduction</h3><p>Bowel urgency affects the quality of life of patients with Crohn’s disease (CD) and ulcerative colitis (UC). This study used data from the Communicating Needs and Features of IBD Experiences (CONFIDE) survey to explore patient and healthcare professional (HCP) perceptions on the broad impacts of bowel urgency on patients’ emotions and daily lives.</p><h3>Methods</h3><p>Online, quantitative, cross-sectional surveys were conducted among patients with moderate-to-severe UC or CD (defined based on previous treatment, steroid use, and/or hospitalization) and HCPs specialized in gastroenterology in Europe (France, Germany, Italy, Spain, UK), United States (US), and Japan. Data were summarized using descriptive statistics.</p><h3>Results</h3><p>The analysis included 200 US, 556 European, and 124 Japanese patients with UC and 215 US, 547 European, and 99 Japanese patients with CD; and 200 US, 503 European, and 100 Japanese HCPs. Patients experiencing bowel urgency in the past month and HCPs reported high emotional (up to: 97% patients, 97% HCPs) and daily life (up to: 85% patients, 97% HCPs) impacts due to bowel urgency in the US, Europe, and Japan. In all geographies, these impacts were similar among patients with UC and CD. Although patients and HCPs reported a broad impact of bowel urgency, HCPs perceived a higher impact than patients, but it was not among the top three most impactful symptoms on HCPs’ treatment decisions.</p><h3>Conclusions</h3><p>Bowel urgency affects the emotions and daily life of patients with UC or CD in the US, Europe, and Japan. A multidisciplinary approach is required to enhance care and develop suitable treatment strategies.</p></div>\",\"PeriodicalId\":7482,\"journal\":{\"name\":\"Advances in Therapy\",\"volume\":\"42 9\",\"pages\":\"4510 - 4526\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://link.springer.com/content/pdf/10.1007/s12325-025-03296-3.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advances in Therapy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12325-025-03296-3\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in Therapy","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12325-025-03296-3","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}
Broad Impact of Bowel Urgency in Ulcerative Colitis and Crohn’s Disease: US, European, and Japanese Patient and Healthcare Professional Perspectives from the Communicating Needs and Features of IBD Experiences (CONFIDE) Survey
Introduction
Bowel urgency affects the quality of life of patients with Crohn’s disease (CD) and ulcerative colitis (UC). This study used data from the Communicating Needs and Features of IBD Experiences (CONFIDE) survey to explore patient and healthcare professional (HCP) perceptions on the broad impacts of bowel urgency on patients’ emotions and daily lives.
Methods
Online, quantitative, cross-sectional surveys were conducted among patients with moderate-to-severe UC or CD (defined based on previous treatment, steroid use, and/or hospitalization) and HCPs specialized in gastroenterology in Europe (France, Germany, Italy, Spain, UK), United States (US), and Japan. Data were summarized using descriptive statistics.
Results
The analysis included 200 US, 556 European, and 124 Japanese patients with UC and 215 US, 547 European, and 99 Japanese patients with CD; and 200 US, 503 European, and 100 Japanese HCPs. Patients experiencing bowel urgency in the past month and HCPs reported high emotional (up to: 97% patients, 97% HCPs) and daily life (up to: 85% patients, 97% HCPs) impacts due to bowel urgency in the US, Europe, and Japan. In all geographies, these impacts were similar among patients with UC and CD. Although patients and HCPs reported a broad impact of bowel urgency, HCPs perceived a higher impact than patients, but it was not among the top three most impactful symptoms on HCPs’ treatment decisions.
Conclusions
Bowel urgency affects the emotions and daily life of patients with UC or CD in the US, Europe, and Japan. A multidisciplinary approach is required to enhance care and develop suitable treatment strategies.
期刊介绍：
Advances in Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged.
The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Advances in Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.
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