1999年至2020年美国先天性心脏病患者肺动脉高压死亡率趋势:CDC WONDER分析

IF 1.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS
Allahdad Khan , Tehreem Asghar , Kumail Mustafa Ali , Muhammad Saeed , Saniya Ishtiaq , Fatima Ashfaq , Jamil Nasrallah , Laiba Yumn , Usman Ali Akbar , Peter Collins , Raheel Ahmed
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引用次数: 0

摘要

先天性心脏病(CHD)是描述出生时各种结构性心脏畸形的总称。冠心病影响约1%的活产婴儿,导致大量成年人患有这些异常。成人冠心病患者的肺动脉高压(PH)是异质性的,基于缺陷的类型和相关条件,但它是已知的不良结果的原因。方法使用ICD代码(I27.0、I27.2、I27.8和I27.9)从CDC-WONDER数据库中检索死亡证明数据。Q20-26)。计算了每10万人的粗死亡率(cmr)和年龄调整死亡率(AAMRs)。采用年变化百分数(APC)和平均年变化百分数(AAPC)进行时间趋势分析。结果1999 - 2020年,死亡率总体呈下降趋势。在美国,患有先天性心脏病和肺动脉高压的男性和女性的死亡率在统计上有显著下降。就种族而言,在白人中,这种下降最为明显。在美国所有四个人口普查地区,先天性心脏病患者因肺动脉高压导致的死亡率在统计上都有显著下降。与城市地区相比,农村地区的下降速度更快。结论:本研究强调,先前实施的有针对性的干预措施显著有助于降低美国先天性心脏病和肺动脉高压患者的死亡率,但在某些地区仍需改进,包括女性、西班牙裔或拉丁裔以及东北和西部地区。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Trends in mortality from pulmonary hypertension amongst population with congenital heart disease in the United States from 1999 to 2020: A CDC WONDER analysis

Trends in mortality from pulmonary hypertension amongst population with congenital heart disease in the United States from 1999 to 2020: A CDC WONDER analysis

Background

Congenital heart disease (CHD) is an umbrella term describing a variety of structural cardiac malformations at birth. CHD affects approximately 1 % of live births, generating a large adult population with these abnormalities. Pulmonary hypertension (PH) in patients with adult CHD is heterogeneous, based on the type of defect and associated conditions, but is a known cause of adverse outcome.

Method

We retrieved death certificate data from the CDC-WONDER database using ICD codes (I27.0, I27.2, I27.8, and I27.9., and Q20-26). Crude mortality rates (CMRs) and age-adjusted mortality rates (AAMRs) per 100,000 persons were calculated. Temporal trends were examined using the annual percent change (APC) and average annual percent change (AAPC) determined by Joinpoint regression.

Result

From 1999 to 2020, an overall declining pattern was observed in the mortality rate. Men and women with congenital heart disease and pulmonary hypertension in the U.S. experienced a statistically significant decline in mortality rates. In terms of races, among White individuals, the decline was the most pronounced. All four U.S. census regions experienced statistically significant declines in mortality due to pulmonary hypertension among individuals with congenital heart disease. The rate of decline was steeper in rural areas compared to urban ones.

Conclusion

This study highlights that previously implemented targeted interventions significantly contributed to the reduction of mortality amongst patiemnts with congenital heart disease and pulmonary hypertension in the U.S. Still improvements are required in certain areas, including female gender, Hispanic or Latino, and the Northeast and West regions.
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来源期刊
International journal of cardiology. Congenital heart disease
International journal of cardiology. Congenital heart disease Cardiology and Cardiovascular Medicine
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