摩洛哥鲍曼不动杆菌碳青霉烯酶编码基因的分子流行病学研究（2019-2024）

IF 0.9 Q4 GENETICS & HEREDITY

Gene Reports Pub Date : 2025-07-07 DOI:10.1016/j.genrep.2025.102289

Hanane El Hafa

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引用次数: 0

摘要

鲍曼不动杆菌已成为院内感染的重要原因，特别是在重症监护病房。它具有对多种抗生素，特别是碳青霉烯类抗生素产生耐药性的显著能力，对全球公共卫生构成严重挑战。本系统综述旨在评估2019 - 2024年摩洛哥鲍曼不动杆菌分离株碳青霉烯酶编码基因的分布和分子特征。我们回顾了有关碳青霉烯酶基因分子检测的文献，包括blaOXA-23、blaOXA-51、blaNDM、blaGES和blaSPM。blaOXA-23是最常检测到的基因，通常与blaOXA-51相关。尽管不太常见，blaNDM、blaGES和blaSPM也有报道，有证据表明在一些分离株中共同检测到多种耐药基因。这些发现强调了摩洛哥卫生保健机构迫切需要分子监测和感染控制战略。

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Molecular epidemiology of carbapenemase-encoding genes in Acinetobacter baumannii isolates from Morocco: A systematic review (2019–2024)

Acinetobacter baumannii has emerged as a significant cause of nosocomial infections, particularly in intensive care units. Its remarkable ability to acquire resistance to a wide range of antibiotics, especially carbapenems, poses a serious global public health challenge. This systematic review aims to assess the distribution and molecular characteristics of carbapenemase-encoding genes in A. baumannii isolates from Morocco between 2019 and 2024. We reviewed indexed publications reporting molecular detection of carbapenemase genes, including blaOXA-23, blaOXA-51, blaNDM, blaGES, and blaSPM. blaOXA-23 was the most frequently detected gene, often found in association with blaOXA-51. Although less common, blaNDM, blaGES, and blaSPM were also reported, with evidence of co-detection of multiple resistance genes in some isolates. These findings underscore the urgent need for molecular surveillance and infection control strategies in Moroccan healthcare settings.

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来源期刊

Gene Reports Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

3.30

自引率

7.70%

发文量

246

审稿时长

49 days

期刊介绍： Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.