{"title":"神经元VPS13D缺失驱动小胶质细胞激活","authors":"Himanish Basu, Coco Holliday, Isaac M. Chiu","doi":"10.1038/s41594-025-01623-4","DOIUrl":null,"url":null,"abstract":"Efficient mitophagy is essential for neuronal health. A study now shows that loss of VPS13D in neurons impairs mitochondrial clearance, gasdermin E activation, mitochondrial DNA release and microglial STING signaling. This neuroimmune mechanism promotes microglial responses that lead to neuronal dysfunction and loss.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"4 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neuronal VPS13D loss drives microglial activation\",\"authors\":\"Himanish Basu, Coco Holliday, Isaac M. Chiu\",\"doi\":\"10.1038/s41594-025-01623-4\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Efficient mitophagy is essential for neuronal health. A study now shows that loss of VPS13D in neurons impairs mitochondrial clearance, gasdermin E activation, mitochondrial DNA release and microglial STING signaling. This neuroimmune mechanism promotes microglial responses that lead to neuronal dysfunction and loss.\",\"PeriodicalId\":18822,\"journal\":{\"name\":\"Nature structural & molecular biology\",\"volume\":\"4 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature structural & molecular biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41594-025-01623-4\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01623-4","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Efficient mitophagy is essential for neuronal health. A study now shows that loss of VPS13D in neurons impairs mitochondrial clearance, gasdermin E activation, mitochondrial DNA release and microglial STING signaling. This neuroimmune mechanism promotes microglial responses that lead to neuronal dysfunction and loss.
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