{"title":"漏溶酶体上的v - atp酶组装","authors":"Alf Håkon Lystad","doi":"10.1038/s41594-025-01612-7","DOIUrl":null,"url":null,"abstract":"Sudden loss of lysosomal acidity triggers a rapid response. Two studies now identify the metazoan RAVE (mRAVE) complex as essential for V-ATPase reassembly and activation under such conditions; map interactions between mRAVE and V-ATPase; and identify a link to CASM, a non-canonical autophagy pathway.","PeriodicalId":18822,"journal":{"name":"Nature structural & molecular biology","volume":"192 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"V-ATPase assembly at leaky lysosomes\",\"authors\":\"Alf Håkon Lystad\",\"doi\":\"10.1038/s41594-025-01612-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Sudden loss of lysosomal acidity triggers a rapid response. Two studies now identify the metazoan RAVE (mRAVE) complex as essential for V-ATPase reassembly and activation under such conditions; map interactions between mRAVE and V-ATPase; and identify a link to CASM, a non-canonical autophagy pathway.\",\"PeriodicalId\":18822,\"journal\":{\"name\":\"Nature structural & molecular biology\",\"volume\":\"192 1\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-07-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature structural & molecular biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s41594-025-01612-7\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature structural & molecular biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s41594-025-01612-7","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Sudden loss of lysosomal acidity triggers a rapid response. Two studies now identify the metazoan RAVE (mRAVE) complex as essential for V-ATPase reassembly and activation under such conditions; map interactions between mRAVE and V-ATPase; and identify a link to CASM, a non-canonical autophagy pathway.
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