冠状动脉疾病患者的出院后癌症和死亡率：一项回顾性队列研究

IF 2.6 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of Geriatric Cardiology Pub Date : 2025-05-28 DOI:10.26599/1671-5411.2025.06.006

Yi-Hao Wang, Shao-Ning Zhu, Ya-Wei Zhao, Kai-Xin Yan, Ming-Zhuang Sun, Zhi-Jun Sun, Yun-Dai Chen, Shun-Ying Hu

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引用次数: 0

摘要

背景：我们对冠状动脉疾病（CAD）患者出院后癌症与死亡率之间的关系了解尚不完整。本研究的目的是探讨冠心病患者出院后癌症与全因死亡率和心血管死亡率之间的关系。方法：在这项回顾性队列研究中，采用SPSS 26.0软件随机纳入2011年1月1日至2015年12月31日期间接受冠状动脉造影的无癌症病史的CAD患者中25%。监测患者出院后癌症的发生率，出院后癌症定义为在住院指数、生存状况和死亡原因后诊断出的癌症。采用Cox回归分析探讨冠心病患者出院后癌症与全因死亡率和心血管死亡率的关系。结果：最终共纳入4085例患者。在中位随访8年期间，174例患者（4.3%）发生出院后癌症，343例患者（8.4%）死亡。共有173名患者死于心血管疾病。出院后癌症与全因死亡风险增加（HR = 2.653, 95% CI: 1.727-4.076, P < 0.001）和心血管死亡风险增加（HR = 2.756, 95% CI: 1.470-5.167, P = 0.002）相关。出院后肺癌（HR = 5.497, 95% CI: 2.922 ~ 10.343, P < 0.001）和胃肠道癌（HR = 1.984, 95% CI: 1.049 ~ 3.750, P = 0.035）与冠心病患者的全因死亡率相关。冠心病患者出院后肺癌与心血管死亡显著相关（HR = 4.979, 95% CI: 2.114-11.728, P < 0.001），心血管死亡与胃肠道癌及其他类型癌症无显著相关。结论：冠心病患者出院后癌症与全因死亡率和心血管死亡率相关。与其他癌症相比，出院后肺癌对CAD患者全因死亡率和心血管死亡率的影响更为显著。

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Postdischarge cancer and mortality in patients with coronary artery disease: a retrospective cohort study.

Background: Our understanding of the correlation between postdischarge cancer and mortality in patients with coronary artery disease (CAD) remains incomplete. The aim of this study was to investigate the relationships between postdischarge cancers and all-cause mortality and cardiovascular mortality in CAD patients.

Methods: In this retrospective cohort study, 25% of CAD patients without prior cancer history who underwent coronary artery angiography between January 1, 2011 and December 31, 2015, were randomly enrolled using SPSS 26.0. Patients were monitored for the incidence of postdischarge cancer, which was defined as cancer diagnosed after the index hospitalization, survival status and cause of death. Cox regression analysis was used to explore the association between postdischarge cancer and all-cause mortality and cardiovascular mortality in CAD patients.

Results: A total of 4085 patients were included in the final analysis. During a median follow-up period of 8 years, 174 patients (4.3%) developed postdischarge cancer, and 343 patients (8.4%) died. A total of 173 patients died from cardiovascular diseases. Postdischarge cancer was associated with increased all-cause mortality risk (HR = 2.653, 95% CI: 1.727-4.076, P < 0.001) and cardiovascular mortality risk (HR = 2.756, 95% CI: 1.470-5.167, P = 0.002). Postdischarge lung cancer (HR = 5.497, 95% CI: 2.922-10.343, P < 0.001) and gastrointestinal cancer (HR = 1.984, 95% CI: 1.049-3.750, P = 0.035) were associated with all-cause mortality in CAD patients. Postdischarge lung cancer was significantly associated with cardiovascular death in CAD patients (HR = 4.979, 95% CI: 2.114-11.728, P < 0.001), and cardiovascular death was not significantly correlated with gastrointestinal cancer or other types of cancer.

Conclusions: Postdischarge cancer was associated with all-cause mortality and cardiovascular mortality in CAD patients. Compared with other cancers, postdischarge lung cancer had a more significant effect on all-cause mortality and cardiovascular mortality in CAD patients.

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来源期刊

Journal of Geriatric Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-GERIATRICS & GERONTOLOGY

CiteScore

3.30

自引率

4.00%

发文量

1161

期刊介绍： JGC focuses on both basic research and clinical practice to the diagnosis and treatment of cardiovascular disease in the aged people, especially those with concomitant disease of other major organ-systems, such as the lungs, the kidneys, liver, central nervous system, gastrointestinal tract or endocrinology, etc.