{"title":"印度北部有机氯农药暴露作为内分泌干扰物与多囊卵巢综合征的关系。","authors":"Ruchika Garg, Binita Goswami, Kamna Singh, Shaifali Singh, Prabhat Agrawal, Prashant Gupta, Urvashi Verma","doi":"10.4103/jmh.jmh_50_25","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim and background: </strong>This study explores the correlation of blood levels of organochlorine pesticides (OCPs) between PCOS and non-PCOS women, considering the endocrine-disrupting properties of OCPs and their potential role in PCOS pathogenesis.</p><p><strong>Materials and methods: </strong>A case-control study was conducted at Sarojini Naidu Medical College, Agra, from September 2022 to March 2024. Serum samples from 110 women diagnosed with PCOS and 110 age- and weight-matched controls were analyzed for 17°CP residues using gas chromatography. Clinical examination to calculate height, weight, body mass index, and waist-hip ratio was conducted. Signs of hyperandrogenism, such as acne and hirsutism, along with acanthosis nigricans, were documented. Hormonal profiles through chemiluminescence immunoassay were assessed. Correlation analysis entails examining connections between OCP and polycystic ovarian syndrome (PCOS) through the application of the Pearson correlation coefficient.</p><p><strong>Results: </strong>PCOS patients exhibited significantly higher levels of several OCPs, including Alpha BHC, Beta BHC, Gamma BHC, Delta BHC, Heptachlor, Heptachlor Epoxide, Endosulfan I, Endosulfan II, Endosulfan Sulfate, Aldrin, Endrin, Endrin Aldehyde, PP-DDE, PP-DDT, and PP-DDD (<i>P</i> < 0.05) in comparison to their age- and weight-matched controls. Dieldrin levels showed no significant difference in both cohorts. Elevated OCP levels correlated with increased androgens, insulin resistance, menstrual irregularities, and disrupted gonadotropin secretion in PCOS patients while no association was measured in controls.</p><p><strong>Conclusion: </strong>The findings suggest that environmental exposure to OCPs is associated with PCOS exacerbates the disease by disrupting hormonal balance and acting as endocrine disruptors. Further research is needed to confirm these associations and inform targeted interventions.</p><p><strong>Clinical significance: </strong>This study highlights the potential role of OCPs in association with PCOS, emphasizing the need for public health measures to reduce exposure to these harmful chemicals, which may help manage PCOS symptoms and improve health outcomes for affected women.</p>","PeriodicalId":37717,"journal":{"name":"Journal of Mid-life Health","volume":"16 2","pages":"201-207"},"PeriodicalIF":1.2000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237234/pdf/","citationCount":"0","resultStr":"{\"title\":\"Association of Organochlorine Pesticide Exposure as Endocrine Disruptors with Polycystic Ovarian Syndrome in North India.\",\"authors\":\"Ruchika Garg, Binita Goswami, Kamna Singh, Shaifali Singh, Prabhat Agrawal, Prashant Gupta, Urvashi Verma\",\"doi\":\"10.4103/jmh.jmh_50_25\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Aim and background: </strong>This study explores the correlation of blood levels of organochlorine pesticides (OCPs) between PCOS and non-PCOS women, considering the endocrine-disrupting properties of OCPs and their potential role in PCOS pathogenesis.</p><p><strong>Materials and methods: </strong>A case-control study was conducted at Sarojini Naidu Medical College, Agra, from September 2022 to March 2024. Serum samples from 110 women diagnosed with PCOS and 110 age- and weight-matched controls were analyzed for 17°CP residues using gas chromatography. Clinical examination to calculate height, weight, body mass index, and waist-hip ratio was conducted. Signs of hyperandrogenism, such as acne and hirsutism, along with acanthosis nigricans, were documented. Hormonal profiles through chemiluminescence immunoassay were assessed. Correlation analysis entails examining connections between OCP and polycystic ovarian syndrome (PCOS) through the application of the Pearson correlation coefficient.</p><p><strong>Results: </strong>PCOS patients exhibited significantly higher levels of several OCPs, including Alpha BHC, Beta BHC, Gamma BHC, Delta BHC, Heptachlor, Heptachlor Epoxide, Endosulfan I, Endosulfan II, Endosulfan Sulfate, Aldrin, Endrin, Endrin Aldehyde, PP-DDE, PP-DDT, and PP-DDD (<i>P</i> < 0.05) in comparison to their age- and weight-matched controls. Dieldrin levels showed no significant difference in both cohorts. Elevated OCP levels correlated with increased androgens, insulin resistance, menstrual irregularities, and disrupted gonadotropin secretion in PCOS patients while no association was measured in controls.</p><p><strong>Conclusion: </strong>The findings suggest that environmental exposure to OCPs is associated with PCOS exacerbates the disease by disrupting hormonal balance and acting as endocrine disruptors. Further research is needed to confirm these associations and inform targeted interventions.</p><p><strong>Clinical significance: </strong>This study highlights the potential role of OCPs in association with PCOS, emphasizing the need for public health measures to reduce exposure to these harmful chemicals, which may help manage PCOS symptoms and improve health outcomes for affected women.</p>\",\"PeriodicalId\":37717,\"journal\":{\"name\":\"Journal of Mid-life Health\",\"volume\":\"16 2\",\"pages\":\"201-207\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237234/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Mid-life Health\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/jmh.jmh_50_25\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/23 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Mid-life Health","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/jmh.jmh_50_25","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/23 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
Association of Organochlorine Pesticide Exposure as Endocrine Disruptors with Polycystic Ovarian Syndrome in North India.
Aim and background: This study explores the correlation of blood levels of organochlorine pesticides (OCPs) between PCOS and non-PCOS women, considering the endocrine-disrupting properties of OCPs and their potential role in PCOS pathogenesis.
Materials and methods: A case-control study was conducted at Sarojini Naidu Medical College, Agra, from September 2022 to March 2024. Serum samples from 110 women diagnosed with PCOS and 110 age- and weight-matched controls were analyzed for 17°CP residues using gas chromatography. Clinical examination to calculate height, weight, body mass index, and waist-hip ratio was conducted. Signs of hyperandrogenism, such as acne and hirsutism, along with acanthosis nigricans, were documented. Hormonal profiles through chemiluminescence immunoassay were assessed. Correlation analysis entails examining connections between OCP and polycystic ovarian syndrome (PCOS) through the application of the Pearson correlation coefficient.
Results: PCOS patients exhibited significantly higher levels of several OCPs, including Alpha BHC, Beta BHC, Gamma BHC, Delta BHC, Heptachlor, Heptachlor Epoxide, Endosulfan I, Endosulfan II, Endosulfan Sulfate, Aldrin, Endrin, Endrin Aldehyde, PP-DDE, PP-DDT, and PP-DDD (P < 0.05) in comparison to their age- and weight-matched controls. Dieldrin levels showed no significant difference in both cohorts. Elevated OCP levels correlated with increased androgens, insulin resistance, menstrual irregularities, and disrupted gonadotropin secretion in PCOS patients while no association was measured in controls.
Conclusion: The findings suggest that environmental exposure to OCPs is associated with PCOS exacerbates the disease by disrupting hormonal balance and acting as endocrine disruptors. Further research is needed to confirm these associations and inform targeted interventions.
Clinical significance: This study highlights the potential role of OCPs in association with PCOS, emphasizing the need for public health measures to reduce exposure to these harmful chemicals, which may help manage PCOS symptoms and improve health outcomes for affected women.
期刊介绍：
Journal of mid-life health is the official journal of the Indian Menopause society published Quarterly in January, April, July and October. It is peer reviewed, scientific journal of mid-life health and its problems. It includes all aspects of mid-life health, preventive as well as curative. The journal publishes on subjects such as gynecology, neurology, geriatrics, psychiatry, endocrinology, urology, andrology, psychology, healthy ageing, cardiovascular health, bone health, quality of life etc. as relevant of men and women in their midlife. The Journal provides a visible platform to the researchers as well as clinicians to publish their experiences in this area thereby helping in the promotion of mid-life health leading to healthy ageing, growing need due to increasing life expectancy. The Editorial team has maintained high standards and published original research papers, case reports and review articles from the best of the best contributors both national & international, consistently so that now, it has become a great tool in the hands of menopause practitioners.
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