妊娠激素对围生期疼痛感知的影响:综述。

IF 1.1 Q3 PHARMACOLOGY & PHARMACY
Amit K Malviya, Anju Gupta, Vinay Kumar, Jasmeen Gupta, Deepika, Puneet Khanna
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引用次数: 0

摘要

怀孕是一个显著的荷尔蒙波动的时期,这可能会影响疼痛感知。被认为对新生儿和母亲安全的镇痛药选择有限。了解妊娠激素对疼痛敏感性的影响对于分娩和产后有效的疼痛管理至关重要。文献显示了令人鼓舞的证据,表明妊娠激素在疼痛调节中的作用,一些研究表明可能会降低疼痛敏感性。研究表明,黄体酮与剖宫产后疼痛评分和麻醉需求降低有关,而催产素水平在一些研究中与剖宫产后疼痛严重程度呈负相关。然而,总体证据仍然不确定,表明需要进一步的研究来阐明怀孕期间和产后激素调节疼痛感知的复杂机制。本文综述了现有的文献,以提供孕激素包括孕酮、雌激素和催产素在妊娠、分娩和围生期疼痛调节中的机制和作用。未来的研究应侧重于阐明妊娠激素影响疼痛感知的机制,并确定可能导致妊娠个体疼痛敏感性变化的个体因素。应计划设计良好的随机对照试验来评估激素治疗对围生期疼痛调节的影响。这些知识将有助于为产科患者提供证据和设计疼痛管理方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Effect of pregnancy hormones on pain perception in the peripartum period: A narrative review.

Effect of pregnancy hormones on pain perception in the peripartum period: A narrative review.

Effect of pregnancy hormones on pain perception in the peripartum period: A narrative review.

Pregnancy is a period marked by significant hormonal fluctuations, which can influence pain perception. There are only a limited number of analgesic options that are considered safe for newborns and mothers. Understanding the impact of pregnancy hormones on pain sensitivity can be crucial for effective pain management during childbirth and the postpartum period. The literature shows encouraging evidence of the role of pregnancy hormones on pain modulation, with some studies suggesting a potential reduction in pain sensitivity. Studies have shown progesterone to be associated with reduced post-cesarean pain scores and anesthesia requirements, while oxytocin levels inversely correlated with post-cesarean pain severity in some studies. However, the overall evidence remains inconclusive, indicating a need for further research to elucidate the complex mechanisms underlying hormonal modulation of pain perception during pregnancy and postpartum accurately. This narrative review summarizes the available literature to provide insights into the mechanisms and role of pregnancy hormones including progesterone, estrogen, and oxytocin in pain modulation during pregnancy, delivery, and the peripartum period. Future research should focus on clarifying the mechanisms through which pregnancy hormones influence pain perception and identifying individual factors that may contribute to variability in pain sensitivity among pregnant individuals. Well-designed randomized controlled trials should be planned to evaluate the effect of hormonal therapy on pain modulation in the peripartum period. This knowledge would help to generate evidence and design pain management protocols for obstetric patients.

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来源期刊
CiteScore
1.90
自引率
6.70%
发文量
129
期刊介绍: The JOACP publishes original peer-reviewed research and clinical work in all branches of anaesthesiology, pain, critical care and perioperative medicine including the application to basic sciences. In addition, the journal publishes review articles, special articles, brief communications/reports, case reports, and reports of new equipment, letters to editor, book reviews and obituaries. It is international in scope and comprehensive in coverage.
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