EML4::NTRK3重排卵巢肿瘤病例报告及文献复习。

IF 1.6 4区医学 Q3 OBSTETRICS & GYNECOLOGY

International Journal of Gynecological Pathology Pub Date : 2025-07-07 DOI:10.1097/PGP.0000000000001122

Steven H Smith, Emily Hinchcliff, Christopher Felicelli

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引用次数: 0

摘要

本病例报告详细介绍了已知的第一例卵巢EML4::NTRK3重排肿瘤。患者，32岁女性，表现为长时间异常子宫出血，并发现有一个5.0厘米的右附件肿块。手术切除后，组织学检查显示梭形细胞呈肿瘤样上皮，具有中度细胞异型性，具有可变黏液样背景，而免疫组织化学证实抑制素、calretinin和平滑肌肌动蛋白（SMA）阳性。分子分析鉴定出EML4::NTRK3融合，确定诊断。这一罕见的发现拓宽了NTRK融合相关妇科肿瘤的范围，通常在子宫中观察到。通过本报告和文献综述，我们旨在提高对NTRK融合阳性卵巢肿瘤的诊断认识，并强调潜在的治疗策略。

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EML4::NTRK3 Rearranged Ovarian Neoplasm: Case Report and Literature Review.

This case report details the first known instance of an EML4::NTRK3 rearranged neoplasm in the ovary. The patient, a 32-yr-old woman, presented with prolonged abnormal uterine bleeding and was found to have a 5.0 cm right adnexal mass. Following surgical excision, histologic examination revealed neoplastic epithelioid to spindled cells with moderate cytologic atypia in a variably myxoid background, while immunohistochemistry confirmed positivity for inhibin, calretinin, and smooth muscle actin (SMA). Molecular analysis identified an EML4::NTRK3 fusion, establishing the diagnosis. This rare finding broadens the spectrum of NTRK fusion-related gynecologic tumors, typically observed in the uterus. Through this report and a literature review, we aim to enhance diagnostic recognition and underscore potential therapeutic strategies for NTRK fusion-positive ovarian tumors.

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来源期刊

International Journal of Gynecological Pathology 医学-病理学

CiteScore

3.90

自引率

12.50%

发文量

154

审稿时长

6-12 weeks

期刊介绍： International Journal of Gynecological Pathology is the official journal of the International Society of Gynecological Pathologists (ISGyP), and provides complete and timely coverage of advances in the understanding and management of gynecological disease. Emphasis is placed on investigations in the field of anatomic pathology. Articles devoted to experimental or animal pathology clearly relevant to an understanding of human disease are published, as are pathological and clinicopathological studies and individual case reports that offer new insights.