Emilia Vataja, Giorgio Ratti, Adrian Safa, Marta Pagano, Luigia Ferrante, Seppo Meri, Karita Haapasalo
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Exploring the intersection of atherosclerosis and Alzheimer's disease: the role of inflammation and complement activation.
Background: Atherosclerosis (AS) and Alzheimer's disease (AD) are both multifactorial in nature and share many risk factors. Vascular dementia and AD may occur together, and a substantial proportion of AD cases also have signs of cardiovascular disease, a relationship well-established by cohort studies. The risk factors could contribute to persistent smoldering inflammation, including activation of complement at sites of endothelial injury and/or by accumulation of molecular aggregates.
Methods: To examine the possible bridging points between AD and AS, we constructed a comprehensive narrative review.
Results: A connecting point between AD and AS is inflammation. Contrary to prior assumptions, a significant linkage exists between systemic inflammation and neuroinflammation. Activities of complement, a key effector of innate immunity, are of special interest in the pathogenesis of both diseases.
Conclusion: AS and AD share a partially overlapping array of pathophysiological mechanisms.
期刊介绍：
Inflammation Research (IR) publishes peer-reviewed papers on all aspects of inflammation and related fields including histopathology, immunological mechanisms, gene expression, mediators, experimental models, clinical investigations and the effect of drugs. Related fields are broadly defined and include for instance, allergy and asthma, shock, pain, joint damage, skin disease as well as clinical trials of relevant drugs.
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