{"title":"老年人每日摄入活微生物和认知功能：线粒体功能障碍的中介作用。","authors":"Shuhua Fang, Nian Yang, Qing Zhao, Jingyi Chen","doi":"10.1080/09637486.2025.2512889","DOIUrl":null,"url":null,"abstract":"<p><p>This study analysed the NHANES (2010-2014) data of 2,312 elderly people to investigate the relationship between dietary intake of live microbes (DLM) and cognitive function and the mediating role of mitochondrial dysfunction between them. Linear regression indicated that the high-DLM group was positively associated with z-score of Digit Symbol Substitution Test (DSST) (β = 0.13, <i>p</i> < 0.05) and global cognitive score (β = 0.37, <i>p</i> < 0.05). Logistic regression showed that high-DLM was a protective factor for cognitive impairment among the elderly (OR = 0.62, <i>p</i> < 0.05). Mediation analysis revealed that circulating methylmalonic acid (MMA) was negatively associated with high-DLM (β = -22.98, <i>p</i> < 0.05) and it exerted a mediating effect on the relationship between the high-DLM group and DSST and global cognitive score, with the mediated proportions of 3.8%, and 4.1%, respectively. Moreover, high-DLM is associated with better cognitive function through its relationship with MMA in older adults.</p>","PeriodicalId":14087,"journal":{"name":"International Journal of Food Sciences and Nutrition","volume":" ","pages":"1-8"},"PeriodicalIF":3.5000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Daily intake of live microbes and cognitive function in older adults: the mediating role of mitochondrial dysfunction.\",\"authors\":\"Shuhua Fang, Nian Yang, Qing Zhao, Jingyi Chen\",\"doi\":\"10.1080/09637486.2025.2512889\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>This study analysed the NHANES (2010-2014) data of 2,312 elderly people to investigate the relationship between dietary intake of live microbes (DLM) and cognitive function and the mediating role of mitochondrial dysfunction between them. Linear regression indicated that the high-DLM group was positively associated with z-score of Digit Symbol Substitution Test (DSST) (β = 0.13, <i>p</i> < 0.05) and global cognitive score (β = 0.37, <i>p</i> < 0.05). Logistic regression showed that high-DLM was a protective factor for cognitive impairment among the elderly (OR = 0.62, <i>p</i> < 0.05). Mediation analysis revealed that circulating methylmalonic acid (MMA) was negatively associated with high-DLM (β = -22.98, <i>p</i> < 0.05) and it exerted a mediating effect on the relationship between the high-DLM group and DSST and global cognitive score, with the mediated proportions of 3.8%, and 4.1%, respectively. Moreover, high-DLM is associated with better cognitive function through its relationship with MMA in older adults.</p>\",\"PeriodicalId\":14087,\"journal\":{\"name\":\"International Journal of Food Sciences and Nutrition\",\"volume\":\" \",\"pages\":\"1-8\"},\"PeriodicalIF\":3.5000,\"publicationDate\":\"2025-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"International Journal of Food Sciences and Nutrition\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.1080/09637486.2025.2512889\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"FOOD SCIENCE & TECHNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Journal of Food Sciences and Nutrition","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.1080/09637486.2025.2512889","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"FOOD SCIENCE & TECHNOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
本研究分析了2312名老年人的NHANES（2010-2014）数据，探讨饮食中活微生物（DLM）摄入与认知功能的关系以及线粒体功能障碍在两者之间的中介作用。线性回归表明，高dlm组与数字符号替代测验（DSST） z-score呈正相关（β = 0.13, p p p p p）
Daily intake of live microbes and cognitive function in older adults: the mediating role of mitochondrial dysfunction.
This study analysed the NHANES (2010-2014) data of 2,312 elderly people to investigate the relationship between dietary intake of live microbes (DLM) and cognitive function and the mediating role of mitochondrial dysfunction between them. Linear regression indicated that the high-DLM group was positively associated with z-score of Digit Symbol Substitution Test (DSST) (β = 0.13, p < 0.05) and global cognitive score (β = 0.37, p < 0.05). Logistic regression showed that high-DLM was a protective factor for cognitive impairment among the elderly (OR = 0.62, p < 0.05). Mediation analysis revealed that circulating methylmalonic acid (MMA) was negatively associated with high-DLM (β = -22.98, p < 0.05) and it exerted a mediating effect on the relationship between the high-DLM group and DSST and global cognitive score, with the mediated proportions of 3.8%, and 4.1%, respectively. Moreover, high-DLM is associated with better cognitive function through its relationship with MMA in older adults.
期刊介绍：
The primary aim of International Journal of Food Sciences and Nutrition is to integrate food science with nutrition. Improvement of knowledge in human nutrition should always be the final objective of submitted research. It''s an international, peer-reviewed journal which publishes high quality, original research contributions to scientific knowledge. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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