肾素-血管紧张素-醛固酮系统在脓毒症中的作用及其治疗靶点

IF 4.7 2区医学 Q2 IMMUNOLOGY

International immunopharmacology Pub Date : 2025-07-10 DOI:10.1016/j.intimp.2025.115192

Xinsen Chen , Meng Shao , Yancun Liu , Juan Zhou , Fengsheng Cao , Yang Liu , Guangyu Qiu , Ting Jiang , Min Huang , Lu Zhang

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引用次数: 0

摘要

宿主对感染的反应不平衡会导致败血症，这是一种潜在的致命疾病。败血症可发展为感染性休克、器官功能障碍（包括脑、肝、肺、肾和心脏）、骨骼肌萎缩和一系列严重并发症。肾素-血管紧张素-醛固酮系统（RAAS）在脓毒症中发生显著改变，其主要生物活性成分的表达与脓毒症患者的预后密切相关。靶向RAAS可能提供治疗败血症及其并发症的有效方法。因此，本文主要综述了脓毒症对循环和组织中关键RAAS成分的活性和表达的影响。我们还讨论了选择性调节RAAS在脓毒症及其相关并发症中的作用和机制。此外，我们介绍了RAAS精确调控的创新观点，旨在优化针对不同阶段败血症和不同并发症的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Role of the renin-angiotensin-aldosterone system in sepsis and its therapeutic targets

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Role of the renin-angiotensin-aldosterone system in sepsis and its therapeutic targets

An imbalance in the host's response to infection causes sepsis, a potentially fatal condition. Sepsis may advance to septic shock, organ dysfunction (including the brain, liver, lung, kidney, and heart), skeletal muscle atrophy, and an array of severe complications. The renin-angiotensin-aldosterone system (RAAS) undergoes significant alterations during sepsis, and the expression of its principal bioactive components is closely associated with the prognosis of patients with sepsis. Targeting RAAS may offer an effective approach to managing sepsis and its complications. Consequently, this review primarily summarizes the impact of sepsis on the activity and expression of key RAAS components in the circulation and tissues. We also discuss the effects and mechanisms of selectively modulating the RAAS in the context of sepsis and its associated complications. Furthermore, we introduce innovative perspectives on the precise regulation of the RAAS with the aim of optimizing treatment strategies tailored to different stages of sepsis and diverse complications.

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来源期刊

International immunopharmacology 医学-免疫学

CiteScore

8.40

自引率

3.60%

发文量

935

审稿时长

53 days

期刊介绍： International Immunopharmacology is the primary vehicle for the publication of original research papers pertinent to the overlapping areas of immunology, pharmacology, cytokine biology, immunotherapy, immunopathology and immunotoxicology. Review articles that encompass these subjects are also welcome. The subject material appropriate for submission includes: • Clinical studies employing immunotherapy of any type including the use of: bacterial and chemical agents; thymic hormones, interferon, lymphokines, etc., in transplantation and diseases such as cancer, immunodeficiency, chronic infection and allergic, inflammatory or autoimmune disorders. • Studies on the mechanisms of action of these agents for specific parameters of immune competence as well as the overall clinical state. • Pre-clinical animal studies and in vitro studies on mechanisms of action with immunopotentiators, immunomodulators, immunoadjuvants and other pharmacological agents active on cells participating in immune or allergic responses. • Pharmacological compounds, microbial products and toxicological agents that affect the lymphoid system, and their mechanisms of action. • Agents that activate genes or modify transcription and translation within the immune response. • Substances activated, generated, or released through immunologic or related pathways that are pharmacologically active. • Production, function and regulation of cytokines and their receptors. • Classical pharmacological studies on the effects of chemokines and bioactive factors released during immunological reactions.