Jing Chen , Yongheng Zhao , Jiao Hu , Zhihang Ye , Chunmei Nan , Pingfei Li , Xincai Hao
{"title":"龙头草多糖组分的研究。并对其抗氧化和免疫调节活性进行评价","authors":"Jing Chen , Yongheng Zhao , Jiao Hu , Zhihang Ye , Chunmei Nan , Pingfei Li , Xincai Hao","doi":"10.1016/j.carpta.2025.100935","DOIUrl":null,"url":null,"abstract":"<div><div>The present work aimed to explore different <em>Trillium tschonoskii</em> Maxim. polysaccharide (TTMPs) fractions derived by ethanol precipitation on the physicochemical properties and biological activities, four new fractions (TTMP-40, TTMP-50, TTMP-60 and TTMP-70) were obtained. TTMPs contained varying proportions of arabinose, glucosamine hydrochloride, galactose, glucose, xylose and galacturonic acid, and exhibited different total sugar content, uronic acid content and protein content. All fractions also showed different molecular weight and microstructure. TTMP-70 displayed the stronger antioxidant activity than that of TTMP-40, TTMP-50 and TTMP-60 in vitro. Furthermore, the immunomodulatory effects of TTMP-70 were mediated through reduction of intracellular ROS, which in turn inhibited H<sub>2</sub>O<sub>2</sub>-induced apoptosis and promoted CD8+ <em>T</em> cell proliferation. These results indicate that TTMP-70 has the potential to be a potent natural antioxidant with clinical and industrial applications.</div></div>","PeriodicalId":100213,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 ","pages":"Article 100935"},"PeriodicalIF":6.5000,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Characterization of polysaccharides fractions from Trillium tschonoskii Maxim. and assessment of their antioxidant and immunomodulatory activities\",\"authors\":\"Jing Chen , Yongheng Zhao , Jiao Hu , Zhihang Ye , Chunmei Nan , Pingfei Li , Xincai Hao\",\"doi\":\"10.1016/j.carpta.2025.100935\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The present work aimed to explore different <em>Trillium tschonoskii</em> Maxim. polysaccharide (TTMPs) fractions derived by ethanol precipitation on the physicochemical properties and biological activities, four new fractions (TTMP-40, TTMP-50, TTMP-60 and TTMP-70) were obtained. TTMPs contained varying proportions of arabinose, glucosamine hydrochloride, galactose, glucose, xylose and galacturonic acid, and exhibited different total sugar content, uronic acid content and protein content. All fractions also showed different molecular weight and microstructure. TTMP-70 displayed the stronger antioxidant activity than that of TTMP-40, TTMP-50 and TTMP-60 in vitro. Furthermore, the immunomodulatory effects of TTMP-70 were mediated through reduction of intracellular ROS, which in turn inhibited H<sub>2</sub>O<sub>2</sub>-induced apoptosis and promoted CD8+ <em>T</em> cell proliferation. These results indicate that TTMP-70 has the potential to be a potent natural antioxidant with clinical and industrial applications.</div></div>\",\"PeriodicalId\":100213,\"journal\":{\"name\":\"Carbohydrate Polymer Technologies and Applications\",\"volume\":\"11 \",\"pages\":\"Article 100935\"},\"PeriodicalIF\":6.5000,\"publicationDate\":\"2025-07-03\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Carbohydrate Polymer Technologies and Applications\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2666893925002762\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Carbohydrate Polymer Technologies and Applications","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666893925002762","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Characterization of polysaccharides fractions from Trillium tschonoskii Maxim. and assessment of their antioxidant and immunomodulatory activities
The present work aimed to explore different Trillium tschonoskii Maxim. polysaccharide (TTMPs) fractions derived by ethanol precipitation on the physicochemical properties and biological activities, four new fractions (TTMP-40, TTMP-50, TTMP-60 and TTMP-70) were obtained. TTMPs contained varying proportions of arabinose, glucosamine hydrochloride, galactose, glucose, xylose and galacturonic acid, and exhibited different total sugar content, uronic acid content and protein content. All fractions also showed different molecular weight and microstructure. TTMP-70 displayed the stronger antioxidant activity than that of TTMP-40, TTMP-50 and TTMP-60 in vitro. Furthermore, the immunomodulatory effects of TTMP-70 were mediated through reduction of intracellular ROS, which in turn inhibited H2O2-induced apoptosis and promoted CD8+ T cell proliferation. These results indicate that TTMP-70 has the potential to be a potent natural antioxidant with clinical and industrial applications.
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