美国成人血红蛋白与红细胞分布宽度比与类风湿关节炎的关系：来自2009-2018年国家健康与营养检查调查的证据

IF 2.4 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Preventive Medicine Reports Pub Date : 2025-07-09 DOI:10.1016/j.pmedr.2025.103169

Nian Kuang , Jing Liu , Zhaoduan Hu , Yanxia Wu , Rui Peng

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引用次数: 0

摘要

目的本横断面研究旨在探讨成人血红蛋白与红细胞分布宽度比（HRR）与类风湿关节炎的关系。方法分析2009-2018年国家健康与营养检查调查（NHANES） 22352名参与者的横断面数据。HRR定义为血红蛋白浓度（g/dL）除以红细胞分布宽度（%），并按四分位数分组。多变量logistic回归模型和限制性三次样条（RCS）模型评估了HRR和类风湿关节炎之间的联系，并根据人口统计学、社会经济因素和合并症进行了调整。结果HRR测量结果与类风湿关节炎易感性呈显著负相关。高HRR四分位数表明类风湿关节炎的风险逐渐降低（四分位数4 vs四分位数1:OR = 0.68, 95% CI: 0.56,0.83）。调整后的RCS显示出负线性相关(P为总体<；0.001；非线性P = 0.174)。结论shrr与类风湿关节炎风险呈负相关，提示其可能作为类风湿关节炎风险分层的生物标志物。然而，需要进一步的调查来证实这些观察结果。

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Association between hemoglobin-to-red blood cell distribution width ratio and rheumatoid arthritis in US adults: evidence from the national health and nutrition examination survey 2009–2018

Objective

This cross-sectional study aimed to investigate the association between the hemoglobin-to-red blood cell distribution width ratio (HRR) and rheumatoid arthritis in adults.

Methods

Cross-sectional data from 22,352 participants in the National Health and Nutrition Examination Survey (NHANES) 2009–2018 were analyzed. HRR was defined as hemoglobin concentration (g/dL) divided by red blood cell distribution width (%) and grouped into quartiles. The multivariable logistic regression model and restricted cubic spline (RCS) models assessed the connection between HRR and rheumatoid arthritis, adjusted for demographics, socioeconomic factors, and comorbidities.

Results

Our findings reveal a significant negative correlation between HRR measurements and rheumatoid arthritis susceptibility. Higher HRR quartiles showed progressively lower rheumatoid arthritis risk (quartile 4 vs. quartile 1: OR = 0.68, 95 % CI: 0.56,0.83). RCS revealed an inverse linear association after adjustment (P for overall <0.001; P for nonlinear = 0.174).

Conclusions

HRR is inversely associated with rheumatoid arthritis risk, suggesting its potential as a biomarker for rheumatoid arthritis risk stratification. Nevertheless, additional investigations are required to corroborate these observations.

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来源期刊

Preventive Medicine Reports Medicine-Public Health, Environmental and Occupational Health

CiteScore

3.90

自引率

0.00%

发文量

353