与变应性疾病实验室相关的肥大细胞研究的进化：1985-2022年在2023年NIAID研讨会上发表。

IF 11.2 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology Pub Date : 2025-09-01 DOI:10.1016/j.jaci.2025.06.029

Hirsh D. Komarow MD , Gunnar Nilsson PhD , Yoshimichi Okayama MD, PhD , Yoseph Mekori MD , Ana Olivera PhD , Peter Valent MD , Karin Hartmann MD , Knut Brockow MD , Glenn Cruse PhD , Jonathan Lyons MD , Amy D. Klion MD , Cem Akin MD, PhD , Jason R. Gotlib MD, MS , Mariana Castells MD, PhD , Stephen J. Galli MD , Dean D. Metcalfe MD, MS , Melody C. Carter MD

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引用次数: 0

摘要

2023年10月，过敏疾病实验室肥大细胞生物学组（MCBS）的现任和前任研究人员及其同事组织了为期一天的研讨会，以表彰由Dean D. Metcalfe博士领导的MCBS的杰出贡献，他最近从该部门的领导职位上退休。研讨会概述了在过去三十年中对人类肥大细胞谱系和区室的科学认识的进展。本文介绍了肥大细胞在健康和疾病、肥大细胞活化和肥大细胞增多症中的肿瘤肥大细胞增殖和功能的机制和分子。本文综述了这些发现对过敏性疾病和肥大细胞疾病的诊断和治疗的影响，以及肥大细胞研究中未满足的需求。本文对这些讨论进行了总结。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Evolution of mast cell research associated with the Laboratory of Allergic Diseases, 1985-2022: Summary of the 2023 NIAID Symposium

Present and former investigators of the Mast Cell Biology Section (MCBS) of the Laboratory of Allergic Diseases (LAD) and their colleagues organized a daylong symposium in October 2023 to honor the outstanding contributions of the MCBS headed by Dr Dean D. Metcalfe, who recently retired from his leadership role in this department. The symposium featured an overview of discoveries that advanced the scientific understanding of the human mast cell (MC) lineage and compartment over the preceding 3 decades. Insights into mechanisms and molecules contributing to MC expansion and function in health and disease, MC activation, and neoplastic MCs in mastocytosis were presented. The impact of these discoveries on the diagnosis and management of allergic diseases and MC disorders, as well as unmet needs in MC research, were reviewed. A summary of these discussions is provided.

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来源期刊

Journal of Allergy and Clinical Immunology 医学-过敏

CiteScore

25.90

自引率

7.70%

发文量

1302

审稿时长

38 days

期刊介绍： The Journal of Allergy and Clinical Immunology is a prestigious publication that features groundbreaking research in the fields of Allergy, Asthma, and Immunology. This influential journal publishes high-impact research papers that explore various topics, including asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases. The articles not only report on clinical trials and mechanistic studies but also provide insights into novel therapies, underlying mechanisms, and important discoveries that contribute to our understanding of these diseases. By sharing this valuable information, the journal aims to enhance the diagnosis and management of patients in the future.