放线菌病的过敏表现：综述。

IF 11.4 1区医学 Q1 ALLERGY

Journal of Allergy and Clinical Immunology Pub Date : 2025-07-07 DOI:10.1016/j.jaci.2025.06.030

Candice N Gard,George E Freigeh,Erin M Janssen

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引用次数: 0

摘要

肌动蛋白病是一种影响肌动蛋白丝成熟和形成的疾病。当放线素病影响免疫细胞时，免疫失调导致特应性疾病、自身免疫、自身炎症和感染增加。许多放射线病，包括Wiskott Aldrich综合征和DOCK8缺乏症，都有突出的特应性表现。随着新的研究和新的临床描述的患者诊断为放线素病，放线素病对过敏途径的影响已经扩大。此外，在特定的患者群体中已经确定了与特应性相关的有效治疗方法。在这里，我们回顾了这些疾病及其过敏表现的文献，描述了目前的治疗方案，并讨论了提供者如何区分放线菌病和一般特应性反应。

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Allergic Manifestations of Actinopathies: A Review.

Actinopathies are conditions that impact the maturation and formation of actin filaments. When actinopathies affect immune cells, immune dysregulation leads to atopic disease, autoimmunity, autoinflammation, and increased infection. Many actinopathies, including Wiskott Aldrich Syndrome and DOCK8 deficiency, have prominent atopic manifestations. With emerging research and new clinical descriptions of patients diagnosed with actinopathies, the impact of actinopathies on allergic pathways has expanded. Furthermore, effective treatments related to atopy have been identified in specific patient groups. Here, we review the literature of these disorders and their allergic manifestations, describe current treatment options, and discuss how providers can differentiate actinopathies from general atopy.

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来源期刊

Journal of Allergy and Clinical Immunology 医学-过敏

CiteScore

25.90

自引率

7.70%

发文量

1302

审稿时长

38 days

期刊介绍： The Journal of Allergy and Clinical Immunology is a prestigious publication that features groundbreaking research in the fields of Allergy, Asthma, and Immunology. This influential journal publishes high-impact research papers that explore various topics, including asthma, food allergy, allergic rhinitis, atopic dermatitis, primary immune deficiencies, occupational and environmental allergy, and other allergic and immunologic diseases. The articles not only report on clinical trials and mechanistic studies but also provide insights into novel therapies, underlying mechanisms, and important discoveries that contribute to our understanding of these diseases. By sharing this valuable information, the journal aims to enhance the diagnosis and management of patients in the future.