Feng Sun, Mingqiu Liu, Yongli Qi, Wenjing Qi, Junyi Li
{"title":"联合治疗慢性化脓性中耳炎的临床症状改善及复发率分析：氧氟沙星与地塞米松联合治疗。","authors":"Feng Sun, Mingqiu Liu, Yongli Qi, Wenjing Qi, Junyi Li","doi":"10.2147/RMHP.S520505","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>To analyze the clinical symptom improvement and recurrence rate of chronic suppurative otitis media (CSOM) patients treated with a combination therapy regimen (combination of ofloxacin and dexamethasone).</p><p><strong>Methods: </strong>Based on the treatment regimen, patients were divided into two groups: the control group was treated with dexamethasone, while the treatment group received a combination of ofloxacin and dexamethasone. The clinical symptom improvement, hearing evaluation, pathogen clearance rate, inflammatory marker detection, adverse reactions, recurrence rate and recurrence rate post-treatment were compared between the two groups.</p><p><strong>Results: </strong>There were no significant differences in the baseline clinical data between the two groups (P > 0.05). The overall clinical efficacy of the treatment group was significantly higher than that of the control group (P < 0.05). After treatment, the improvements in air conduction (AC) and air-bone gap (ABG) in the treatment group were significantly greater than those in the control group (P < 0.05). The time for the resolution of tympanic membrane congestion and the healing of perforations was shorter in the treatment group compared to the control group (P < 0.05). The pathogen clearance rate in the treatment group was significantly higher than in the control group (P < 0.05). After treatment, levels of inflammatory markers IL-8, TGF-β1, and PCT in the treatment group were significantly lower than those in the control group (P < 0.05).</p><p><strong>Conclusion: </strong>The combination therapy of ofloxacin and dexamethasone significantly improves the clinical symptoms, reduces the recurrence rate, and lowers the incidence of adverse reactions in chronic suppurative otitis media patients. It shows significant clinical efficacy with improved hearing outcomes, and is worthy of clinical promotion. However, this study still has certain limitations, such as the possibility of introducing selection bias. In the future, prospective clinical trials with multiple centers and large samples can be conducted.</p>","PeriodicalId":56009,"journal":{"name":"Risk Management and Healthcare Policy","volume":"18 ","pages":"2275-2285"},"PeriodicalIF":2.0000,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236466/pdf/","citationCount":"0","resultStr":"{\"title\":\"Analysis of the Clinical Symptom Improvement and Recurrence Rate in Chronic Suppurative Otitis Media Patients Treated with Combination Therapy: Combination of Ofloxacin and Dexamethasone.\",\"authors\":\"Feng Sun, Mingqiu Liu, Yongli Qi, Wenjing Qi, Junyi Li\",\"doi\":\"10.2147/RMHP.S520505\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>To analyze the clinical symptom improvement and recurrence rate of chronic suppurative otitis media (CSOM) patients treated with a combination therapy regimen (combination of ofloxacin and dexamethasone).</p><p><strong>Methods: </strong>Based on the treatment regimen, patients were divided into two groups: the control group was treated with dexamethasone, while the treatment group received a combination of ofloxacin and dexamethasone. The clinical symptom improvement, hearing evaluation, pathogen clearance rate, inflammatory marker detection, adverse reactions, recurrence rate and recurrence rate post-treatment were compared between the two groups.</p><p><strong>Results: </strong>There were no significant differences in the baseline clinical data between the two groups (P > 0.05). The overall clinical efficacy of the treatment group was significantly higher than that of the control group (P < 0.05). After treatment, the improvements in air conduction (AC) and air-bone gap (ABG) in the treatment group were significantly greater than those in the control group (P < 0.05). The time for the resolution of tympanic membrane congestion and the healing of perforations was shorter in the treatment group compared to the control group (P < 0.05). The pathogen clearance rate in the treatment group was significantly higher than in the control group (P < 0.05). After treatment, levels of inflammatory markers IL-8, TGF-β1, and PCT in the treatment group were significantly lower than those in the control group (P < 0.05).</p><p><strong>Conclusion: </strong>The combination therapy of ofloxacin and dexamethasone significantly improves the clinical symptoms, reduces the recurrence rate, and lowers the incidence of adverse reactions in chronic suppurative otitis media patients. It shows significant clinical efficacy with improved hearing outcomes, and is worthy of clinical promotion. However, this study still has certain limitations, such as the possibility of introducing selection bias. In the future, prospective clinical trials with multiple centers and large samples can be conducted.</p>\",\"PeriodicalId\":56009,\"journal\":{\"name\":\"Risk Management and Healthcare Policy\",\"volume\":\"18 \",\"pages\":\"2275-2285\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-07-04\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236466/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Risk Management and Healthcare Policy\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/RMHP.S520505\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"HEALTH CARE SCIENCES & SERVICES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Risk Management and Healthcare Policy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/RMHP.S520505","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"HEALTH CARE SCIENCES & SERVICES","Score":null,"Total":0}
Analysis of the Clinical Symptom Improvement and Recurrence Rate in Chronic Suppurative Otitis Media Patients Treated with Combination Therapy: Combination of Ofloxacin and Dexamethasone.
Objective: To analyze the clinical symptom improvement and recurrence rate of chronic suppurative otitis media (CSOM) patients treated with a combination therapy regimen (combination of ofloxacin and dexamethasone).
Methods: Based on the treatment regimen, patients were divided into two groups: the control group was treated with dexamethasone, while the treatment group received a combination of ofloxacin and dexamethasone. The clinical symptom improvement, hearing evaluation, pathogen clearance rate, inflammatory marker detection, adverse reactions, recurrence rate and recurrence rate post-treatment were compared between the two groups.
Results: There were no significant differences in the baseline clinical data between the two groups (P > 0.05). The overall clinical efficacy of the treatment group was significantly higher than that of the control group (P < 0.05). After treatment, the improvements in air conduction (AC) and air-bone gap (ABG) in the treatment group were significantly greater than those in the control group (P < 0.05). The time for the resolution of tympanic membrane congestion and the healing of perforations was shorter in the treatment group compared to the control group (P < 0.05). The pathogen clearance rate in the treatment group was significantly higher than in the control group (P < 0.05). After treatment, levels of inflammatory markers IL-8, TGF-β1, and PCT in the treatment group were significantly lower than those in the control group (P < 0.05).
Conclusion: The combination therapy of ofloxacin and dexamethasone significantly improves the clinical symptoms, reduces the recurrence rate, and lowers the incidence of adverse reactions in chronic suppurative otitis media patients. It shows significant clinical efficacy with improved hearing outcomes, and is worthy of clinical promotion. However, this study still has certain limitations, such as the possibility of introducing selection bias. In the future, prospective clinical trials with multiple centers and large samples can be conducted.
期刊介绍：
Risk Management and Healthcare Policy is an international, peer-reviewed, open access journal focusing on all aspects of public health, policy and preventative measures to promote good health and improve morbidity and mortality in the population. Specific topics covered in the journal include:
Public and community health
Policy and law
Preventative and predictive healthcare
Risk and hazard management
Epidemiology, detection and screening
Lifestyle and diet modification
Vaccination and disease transmission/modification programs
Health and safety and occupational health
Healthcare services provision
Health literacy and education
Advertising and promotion of health issues
Health economic evaluations and resource management
Risk Management and Healthcare Policy focuses on human interventional and observational research. The journal welcomes submitted papers covering original research, clinical and epidemiological studies, reviews and evaluations, guidelines, expert opinion and commentary, and extended reports. Case reports will only be considered if they make a valuable and original contribution to the literature. The journal does not accept study protocols, animal-based or cell line-based studies.
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