印度第一例分子确诊的肺泡包虫病患者：来自印度北部三级医院的病例报告

IF 1.4 4区医学 Q4 IMMUNOLOGY

Indian Journal of Medical Microbiology Pub Date : 2025-07-01 DOI:10.1016/j.ijmmb.2025.100904

Reetu Kundu , Ayush Vasisth , Falguni Singh Rathore , Sohil Chauhan , Aravind Sekar , Jimil Shah , Sumeeta Khurana

{"title":"印度第一例分子确诊的肺泡包虫病患者：来自印度北部三级医院的病例报告","authors":"Reetu Kundu , Ayush Vasisth , Falguni Singh Rathore , Sohil Chauhan , Aravind Sekar , Jimil Shah , Sumeeta Khurana","doi":"10.1016/j.ijmmb.2025.100904","DOIUrl":null,"url":null,"abstract":"<div><div>Alveolar echinococcosis, caused by <em>Echinococcus multilocularis</em>, is rare in India. We present the first molecularly confirmed AE case from Kashmir, India who presented with a hepatic mass mimicking metastatic malignancy. Imaging revealed a large liver lesion with intrahepatic biliary obstruction. Cytological examination showed necrosis and laminated membranes without hooklets or brood capsules. Polymerase chain reaction (PCR) identified <em>E. multilocularis</em>. The patient underwent albendazole therapy and right hepatectomy, but her condition deteriorated due to post-hepatectomy liver failure, leading to multiorgan dysfunction and death. This case highlights AE's diagnostic complexity in non-endemic regions and underscores the critical role of molecular diagnostics.</div></div>","PeriodicalId":13284,"journal":{"name":"Indian Journal of Medical Microbiology","volume":"56 ","pages":"Article 100904"},"PeriodicalIF":1.4000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"First molecular confirmed patient of alveolar echinococcosis in India: Case report from a tertiary care hospital in North India\",\"authors\":\"Reetu Kundu , Ayush Vasisth , Falguni Singh Rathore , Sohil Chauhan , Aravind Sekar , Jimil Shah , Sumeeta Khurana\",\"doi\":\"10.1016/j.ijmmb.2025.100904\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Alveolar echinococcosis, caused by <em>Echinococcus multilocularis</em>, is rare in India. We present the first molecularly confirmed AE case from Kashmir, India who presented with a hepatic mass mimicking metastatic malignancy. Imaging revealed a large liver lesion with intrahepatic biliary obstruction. Cytological examination showed necrosis and laminated membranes without hooklets or brood capsules. Polymerase chain reaction (PCR) identified <em>E. multilocularis</em>. The patient underwent albendazole therapy and right hepatectomy, but her condition deteriorated due to post-hepatectomy liver failure, leading to multiorgan dysfunction and death. This case highlights AE's diagnostic complexity in non-endemic regions and underscores the critical role of molecular diagnostics.</div></div>\",\"PeriodicalId\":13284,\"journal\":{\"name\":\"Indian Journal of Medical Microbiology\",\"volume\":\"56 \",\"pages\":\"Article 100904\"},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Indian Journal of Medical Microbiology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0255085725001173\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Medical Microbiology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0255085725001173","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"IMMUNOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

由多房棘球绦虫引起的肺泡棘球蚴病在印度很少见。我们提出了第一个分子证实的AE病例从克什米尔，印度谁提出了肝脏肿块模拟转移性恶性肿瘤。影像学显示一大块肝脏病变伴肝内胆道阻塞。细胞学检查显示坏死，膜层状，无钩状或卵囊。聚合酶链反应（PCR）鉴定了多房棘球蚴。患者接受阿苯达唑治疗和右肝切除术，但由于肝切除术后肝功能衰竭，病情恶化，导致多器官功能障碍和死亡。该病例突出了AE在非流行地区的诊断复杂性，并强调了分子诊断的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

First molecular confirmed patient of alveolar echinococcosis in India: Case report from a tertiary care hospital in North India

Alveolar echinococcosis, caused by Echinococcus multilocularis, is rare in India. We present the first molecularly confirmed AE case from Kashmir, India who presented with a hepatic mass mimicking metastatic malignancy. Imaging revealed a large liver lesion with intrahepatic biliary obstruction. Cytological examination showed necrosis and laminated membranes without hooklets or brood capsules. Polymerase chain reaction (PCR) identified E. multilocularis. The patient underwent albendazole therapy and right hepatectomy, but her condition deteriorated due to post-hepatectomy liver failure, leading to multiorgan dysfunction and death. This case highlights AE's diagnostic complexity in non-endemic regions and underscores the critical role of molecular diagnostics.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Indian Journal of Medical Microbiology IMMUNOLOGY-

CiteScore

2.20

自引率

0.00%

发文量

154

审稿时长

73 days

期刊介绍： Manuscripts of high standard in the form of original research, multicentric studies, meta analysis, are accepted. Current reports can be submitted as brief communications. Case reports must include review of current literature, clinical details, outcome and follow up. Letters to the editor must be a comment on or pertain to a manuscript already published in the IJMM or in relation to preliminary communication of a larger study. Review articles, Special Articles or Guest Editorials are accepted on invitation.