槲皮素作为抗糖尿病药物的潜在应用：从分子机制到递送系统设计

IF 6.7 1区医学 Q1 CHEMISTRY, MEDICINAL

Phytomedicine Pub Date : 2025-07-01 DOI:10.1016/j.phymed.2025.157036

Fang LIU , Binbin ZHAO , Qi WANG , Zihan LEI , David Julian McClements , Suqing WANG , Shuai CHEN

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引用次数: 0

摘要

槲皮素是一种天然的类黄酮，已被证明对糖尿病有保护作用。但其水溶性差和化学不稳定性严重阻碍了其临床应用。纳米胶囊化策略作为提高槲皮素生物利用度和治疗效果的一种有前景的方法，在糖尿病治疗领域受到越来越多的关注。目的本文综述了槲皮素的抗糖尿病作用，强调了槲皮素作为抗糖尿病营养品的挑战以及纳米胶囊技术提高其治疗效果的潜力。方法利用PubMed、Web of Science、Scopus、Cochrane Library等数据库，针对槲皮素、糖尿病、纳米颗粒等相关关键词进行综合文献综述。该分析主要关注从每个数据库建立到2025年2月期间发表的文章。结果利用脂质、聚合物和无机纳米颗粒等多种纳米载体，制备了槲皮素的载体。这些纳米制剂显著提高了槲皮素的稳定性、水溶性和细胞吸收率。来自体外和体内研究的临床前证据支持槲皮素负载纳米颗粒在糖尿病干预中的治疗前景。据我们所知，这是第一次专门关注槲皮素纳米颗粒在糖尿病治疗中的应用。总的来说，纳米胶囊化策略大大提高了槲皮素的生物利用度，从而提高了临床前模型中的抗糖尿病效果。然而，需要严格设计的大规模临床试验来验证它们在人体中的安全性和有效性，并使临床转化成为可能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Potential application of quercetin as an anti-diabetic treatment: From molecular mechanism to delivery system design

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Potential application of quercetin as an anti-diabetic treatment: From molecular mechanism to delivery system design

Background

Quercetin, a natural flavonoid, has demonstrated protective effects against diabetes. Nevertheless, its poor aqueous solubility and chemical instability significantly hinder its clinical application. Nanoencapsulation strategies have emerged as promising approaches to enhance the bioavailability and therapeutic efficacy of quercetin, attracting increasing attention in the field of diabetes management.

Purpose

This review critically discussed the anti-diabetic effects of quercetin, highlighting both the challenges of using quercetin as an anti-diabetic nutraceutical and the promising potential of nanoencapsulation techniques to enhance its therapeutic efficacy.

Methods

A comprehensive literature review was conducted using databases like PubMed, Web of Science, Scopus, and Cochrane Library, employing targeted keywords related to quercetin, diabetes, and nanoparticles. The analysis primarily focused on articles published from the inception of each database through February 2025.

Results

Various nanoparticle carriers, such as lipid-based, polymer-based, and inorganic nanoparticles, had been utilized for the delivery of quercetin. These nanoformulations markedly improved the stability, aqueous solubility, and cellular absorption of quercetin. Preclinical evidence from both in vitro and in vivo studies supported the therapeutic promise of quercetin-loaded nanoparticles in diabetes intervention.

Conclusion

To our knowledge, this was the first review to specifically focus on applying quercetin-loaded nanoparticles in diabetes therapy. Overall, nanoencapsulation strategies substantially enhance the bioavailability of quercetin, leading to improved anti-diabetic efficacy in preclinical models. Nevertheless, rigorously designed, large-scale clinical trials are required to validate their safety and efficacy in humans and to enable clinical translation.

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来源期刊

Phytomedicine 医学-药学

CiteScore

10.30

自引率

5.10%

发文量

670

审稿时长

91 days

期刊介绍： Phytomedicine is a therapy-oriented journal that publishes innovative studies on the efficacy, safety, quality, and mechanisms of action of specified plant extracts, phytopharmaceuticals, and their isolated constituents. This includes clinical, pharmacological, pharmacokinetic, and toxicological studies of herbal medicinal products, preparations, and purified compounds with defined and consistent quality, ensuring reproducible pharmacological activity. Founded in 1994, Phytomedicine aims to focus and stimulate research in this field and establish internationally accepted scientific standards for pharmacological studies, proof of clinical efficacy, and safety of phytomedicines.