芳硼酸酯与二烷基亚磷酸酯直接C-P偶联制备芳膦酸酯的简便方法

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-07-10 DOI:10.1016/j.tetlet.2025.155727

Moriah K. McLellan, Jack T. Hemphill, Sarah J. Petty, Josef D. Daniels, Isabel Serrano, Stephen C. Gaylor, Sheiva Iranfar, Nikita Shibkov, Braylon J. Bailey, Timothy B. Clark

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引用次数: 0

摘要

芳基膦酸盐是有价值的农用化学品、药品和膦配体前体。通过金属催化的碳磷偶联反应获得芳基膦酸盐简化了它们的合成。结合到芳基硼酸酯是特别感兴趣的基于许多方法安装硼酸酯到芳烃。研究了钯催化二烷基亚磷酸酯与芳基硼酸酯的微波偶联反应，得到了多种芳基膦酸盐。该方法的重点是C-H硼化/C-P偶联的流线型序列，从简单芳烃生成芳基膦酸盐。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Expedient synthesis of arylphosphonates by the direct C–P coupling of arylboronate esters with dialkyl phosphites

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Expedient synthesis of arylphosphonates by the direct C–P coupling of arylboronate esters with dialkyl phosphites

Arylphosphonates are valuable agrochemicals, pharmaceuticals and phosphine ligand precursors. Accessing arylphosphonates through metal-catalyzed carbon‑phosphorus coupling reactions has simplified their syntheses. The coupling to arylboronate esters is of particular interest based on the numerous methods that install boronate esters into arenes. The palladium-catalyzed coupling of dialkylphosphites with arylboronate esters was developed using microwave heating, providing a variety of arylphosphonates. The method is highlighted by a streamlined sequence of C–H borylation/C-P coupling to generate arylphosphonates from simple arenes.

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.