转基因小鼠的自主生物发光

IF 12.5 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Advances Pub Date : 2025-07-09 DOI:10.1126/sciadv.ads0463

Kamila A. Kiszka, Christian Dullin, Heinz Steffens, Tanja Koenen, Ellen Rothermel, Frauke Alves, Carola Gregor

引用次数: 0

摘要

该细菌生物发光系统可用于在哺乳动物细胞中产生自主生物发光。到目前为止，该系统只被稳定地植入体外培养的细胞中。在这里，我们报道了一种表达细菌生物发光系统基因的自身生物发光转基因小鼠系的产生，使活体哺乳动物的无底物体内发光成像成为可能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Autonomous bioluminescence emission from transgenic mice

查看原文本刊更多论文

Autonomous bioluminescence emission from transgenic mice

The bacterial bioluminescence system can be applied to produce autonomous bioluminescence in mammalian cells. Until now, the system has only been stably inserted into cells cultured in vitro. Here, we report the generation of an autobioluminescent transgenic mouse line constitutively expressing the genes of the bacterial bioluminescence system, enabling substrate-free in vivo luminescence imaging of a living mammal.

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来源期刊

Science Advances 综合性期刊-综合性期刊

CiteScore

21.40

自引率

1.50%

发文量

1937

审稿时长

29 weeks

期刊介绍： Science Advances, an open-access journal by AAAS, publishes impactful research in diverse scientific areas. It aims for fair, fast, and expert peer review, providing freely accessible research to readers. Led by distinguished scientists, the journal supports AAAS's mission by extending Science magazine's capacity to identify and promote significant advances. Evolving digital publishing technologies play a crucial role in advancing AAAS's global mission for science communication and benefitting humankind.