I型干扰素给淋球菌带来了甜蜜的待遇和生存的机会

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2025-07-09 DOI:10.1016/j.chom.2025.05.019

Joseph P. Dillard

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引用次数: 0

摘要

在这一期中，Kurt-Jones等人展示了I型干扰素（IFN-ε）在女性生殖道淋病奈瑟菌感染中的惊人作用。而不是保护宿主，IFN-ε增加了上皮细胞中cmp -唾液酸的产生，增强了唾液酸对细菌低脂糖的修饰，使先天免疫逃逸。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Type I interferons give gonococci a sweet treat and a chance at survival

In this issue, Kurt-Jones et al. demonstrate a surprising role for the type I interferon, IFN-ε, in Neisseria gonorrhoeae infections of the female reproductive tract. Rather than protecting the host, IFN-ε increases CMP-sialic acid production in epithelial cells, potentiating sialic acid modification of bacterial lipooligosaccharide, enabling innate immune evasion.

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.