一种新型手性三齿P*NN配体催化简单酮的不对称（转移）加氢反应

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-07-09 DOI:10.1002/adsc.70011

Bin Li, Jingfeng Zhang, Yu Ding, Danqing Ji, Zexing Lu, Guidong Yang, Shengyong Zhang, Huifang Nie

{"title":"一种新型手性三齿P*NN配体催化简单酮的不对称（转移）加氢反应","authors":"Bin Li, Jingfeng Zhang, Yu Ding, Danqing Ji, Zexing Lu, Guidong Yang, Shengyong Zhang, Huifang Nie","doi":"10.1002/adsc.70011","DOIUrl":null,"url":null,"abstract":"A novel chiral P*NN ligand featuring a P-chirality has been synthesized, and its catalytic properties in Manganese(I)-catalyzed asymmetric hydrogenation and asymmetric transfer hydrogenation of ketones are investigated. A broad range of substrates (42 examples) are hydrogenated, delivering a series of chiral alcohols with outstanding yields (>90%) and good enantioselectivities (up to 92% ee). In addition, a plausible catalytic cycle is performed through deuterium-labeling experiments and high-resolution mass spectrometry analysis.","PeriodicalId":118,"journal":{"name":"Advanced Synthesis & Catalysis","volume":"367 16","pages":""},"PeriodicalIF":4.0000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Manganese(I)-Catalyzed Asymmetric (Transfer) Hydrogenation of Simple Ketones by a Novel Chiral Tridentate P*NN Ligand\",\"authors\":\"Bin Li, Jingfeng Zhang, Yu Ding, Danqing Ji, Zexing Lu, Guidong Yang, Shengyong Zhang, Huifang Nie\",\"doi\":\"10.1002/adsc.70011\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"A novel chiral P*NN ligand featuring a P-chirality has been synthesized, and its catalytic properties in Manganese(I)-catalyzed asymmetric hydrogenation and asymmetric transfer hydrogenation of ketones are investigated. A broad range of substrates (42 examples) are hydrogenated, delivering a series of chiral alcohols with outstanding yields (>90%) and good enantioselectivities (up to 92% ee). In addition, a plausible catalytic cycle is performed through deuterium-labeling experiments and high-resolution mass spectrometry analysis.\",\"PeriodicalId\":118,\"journal\":{\"name\":\"Advanced Synthesis & Catalysis\",\"volume\":\"367 16\",\"pages\":\"\"},\"PeriodicalIF\":4.0000,\"publicationDate\":\"2025-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Advanced Synthesis & Catalysis\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adsc.70011\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Synthesis & Catalysis","FirstCategoryId":"92","ListUrlMain":"https://advanced.onlinelibrary.wiley.com/doi/10.1002/adsc.70011","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

摘要

合成了一种具有P‐手性的新型手性P*NN配体，研究了其在锰(I)催化的酮类不对称氢化和不对称转移氢化反应中的催化性能。广泛的底物（42个例子）被氢化，产生一系列手性醇，具有优异的收率（>90%）和良好的对映选择性（高达92% ee）。此外，通过氘标记实验和高分辨率质谱分析进行了合理的催化循环。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Manganese(I)-Catalyzed Asymmetric (Transfer) Hydrogenation of Simple Ketones by a Novel Chiral Tridentate P*NN Ligand

查看原文本刊更多论文

Manganese(I)-Catalyzed Asymmetric (Transfer) Hydrogenation of Simple Ketones by a Novel Chiral Tridentate P*NN Ligand

A novel chiral P*NN ligand featuring a P-chirality has been synthesized, and its catalytic properties in Manganese(I)-catalyzed asymmetric hydrogenation and asymmetric transfer hydrogenation of ketones are investigated. A broad range of substrates (42 examples) are hydrogenated, delivering a series of chiral alcohols with outstanding yields (>90%) and good enantioselectivities (up to 92% ee). In addition, a plausible catalytic cycle is performed through deuterium-labeling experiments and high-resolution mass spectrometry analysis.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.