基于i型光敏剂的金属超分子纳米纤维协同抗菌治疗。

Shibo Lyu, Lukun Li, Jingdong Gao, Dapeng Liu, Fengling Song
{"title":"基于i型光敏剂的金属超分子纳米纤维协同抗菌治疗。","authors":"Shibo Lyu, Lukun Li, Jingdong Gao, Dapeng Liu, Fengling Song","doi":"10.1002/smo.20240037","DOIUrl":null,"url":null,"abstract":"<p><p>Photodynamic therapy (PDT) has shown great merits in treating microbial infections due to its absence of bacterial resistance. However, the pronounced hypoxic microenvironment in the bacterial infections limits the therapeutic efficiency of traditional type-II PDT, which is highly dependent on oxygen. Here type-I photosensitizer BTZ<sub>n</sub>-Py (<i>n</i> = 8, 20) coordinates with chemical antibacterial agent Ag<sup>+</sup> to fabricate metallo-supramolecular nanofibers. Under light irradiation, the formed nanofibers could not only generate type-II reactive oxygen species (ROS), <sup>1</sup>O<sub>2</sub>, but also produce type-I ROS O<sub>2</sub> <sup>•-</sup> which addressed the hypoxic issues within infected tissues. Moreover, the acid- and photo-active Ag<sup>+</sup> release from the nanofibers endowed the metallo-supramolecular nanofibers with controlled release characteristic, which showed good biocompatibility to normal tissues. Owing to controlled Ag<sup>+</sup> release and photoinduced type-I ROS, the in vitro and in vivo experiments confirmed the significantly synergistic antibacterial performance of the metallo-supramolecular fibers against both Gram-positive and Gram-negative bacteria.</p>","PeriodicalId":520929,"journal":{"name":"Smart molecules : open access","volume":"2 4","pages":"e20240037"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118169/pdf/","citationCount":"0","resultStr":"{\"title\":\"Metallo-supramolecular nanofibers based on type-I photosensitizer for synergistic antibacterial therapy.\",\"authors\":\"Shibo Lyu, Lukun Li, Jingdong Gao, Dapeng Liu, Fengling Song\",\"doi\":\"10.1002/smo.20240037\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Photodynamic therapy (PDT) has shown great merits in treating microbial infections due to its absence of bacterial resistance. However, the pronounced hypoxic microenvironment in the bacterial infections limits the therapeutic efficiency of traditional type-II PDT, which is highly dependent on oxygen. Here type-I photosensitizer BTZ<sub>n</sub>-Py (<i>n</i> = 8, 20) coordinates with chemical antibacterial agent Ag<sup>+</sup> to fabricate metallo-supramolecular nanofibers. Under light irradiation, the formed nanofibers could not only generate type-II reactive oxygen species (ROS), <sup>1</sup>O<sub>2</sub>, but also produce type-I ROS O<sub>2</sub> <sup>•-</sup> which addressed the hypoxic issues within infected tissues. Moreover, the acid- and photo-active Ag<sup>+</sup> release from the nanofibers endowed the metallo-supramolecular nanofibers with controlled release characteristic, which showed good biocompatibility to normal tissues. Owing to controlled Ag<sup>+</sup> release and photoinduced type-I ROS, the in vitro and in vivo experiments confirmed the significantly synergistic antibacterial performance of the metallo-supramolecular fibers against both Gram-positive and Gram-negative bacteria.</p>\",\"PeriodicalId\":520929,\"journal\":{\"name\":\"Smart molecules : open access\",\"volume\":\"2 4\",\"pages\":\"e20240037\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118169/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Smart molecules : open access\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/smo.20240037\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Smart molecules : open access","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/smo.20240037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

光动力疗法(PDT)由于其无细菌耐药性,在治疗微生物感染方面显示出很大的优点。然而,细菌感染中明显的缺氧微环境限制了传统的ii型PDT的治疗效果,这是高度依赖氧气的。本文采用i型光敏剂BTZn-Py (n = 8,20)与化学抗菌剂Ag+配合制备金属超分子纳米纤维。在光照射下,形成的纳米纤维不仅能产生ii型活性氧(ROS) 1O2,还能产生i型活性氧O2•-,解决了感染组织内的缺氧问题。此外,纳米纤维的酸性和光活性Ag+释放使金属超分子纳米纤维具有控释特性,对正常组织具有良好的生物相容性。由于控制Ag+释放和光诱导i型ROS,体外和体内实验证实了金属超分子纤维对革兰氏阳性和革兰氏阴性细菌的显著协同抗菌性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metallo-supramolecular nanofibers based on type-I photosensitizer for synergistic antibacterial therapy.

Photodynamic therapy (PDT) has shown great merits in treating microbial infections due to its absence of bacterial resistance. However, the pronounced hypoxic microenvironment in the bacterial infections limits the therapeutic efficiency of traditional type-II PDT, which is highly dependent on oxygen. Here type-I photosensitizer BTZn-Py (n = 8, 20) coordinates with chemical antibacterial agent Ag+ to fabricate metallo-supramolecular nanofibers. Under light irradiation, the formed nanofibers could not only generate type-II reactive oxygen species (ROS), 1O2, but also produce type-I ROS O2 •- which addressed the hypoxic issues within infected tissues. Moreover, the acid- and photo-active Ag+ release from the nanofibers endowed the metallo-supramolecular nanofibers with controlled release characteristic, which showed good biocompatibility to normal tissues. Owing to controlled Ag+ release and photoinduced type-I ROS, the in vitro and in vivo experiments confirmed the significantly synergistic antibacterial performance of the metallo-supramolecular fibers against both Gram-positive and Gram-negative bacteria.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信