Shibo Lyu, Lukun Li, Jingdong Gao, Dapeng Liu, Fengling Song
{"title":"基于i型光敏剂的金属超分子纳米纤维协同抗菌治疗。","authors":"Shibo Lyu, Lukun Li, Jingdong Gao, Dapeng Liu, Fengling Song","doi":"10.1002/smo.20240037","DOIUrl":null,"url":null,"abstract":"<p><p>Photodynamic therapy (PDT) has shown great merits in treating microbial infections due to its absence of bacterial resistance. However, the pronounced hypoxic microenvironment in the bacterial infections limits the therapeutic efficiency of traditional type-II PDT, which is highly dependent on oxygen. Here type-I photosensitizer BTZ<sub>n</sub>-Py (<i>n</i> = 8, 20) coordinates with chemical antibacterial agent Ag<sup>+</sup> to fabricate metallo-supramolecular nanofibers. Under light irradiation, the formed nanofibers could not only generate type-II reactive oxygen species (ROS), <sup>1</sup>O<sub>2</sub>, but also produce type-I ROS O<sub>2</sub> <sup>•-</sup> which addressed the hypoxic issues within infected tissues. Moreover, the acid- and photo-active Ag<sup>+</sup> release from the nanofibers endowed the metallo-supramolecular nanofibers with controlled release characteristic, which showed good biocompatibility to normal tissues. Owing to controlled Ag<sup>+</sup> release and photoinduced type-I ROS, the in vitro and in vivo experiments confirmed the significantly synergistic antibacterial performance of the metallo-supramolecular fibers against both Gram-positive and Gram-negative bacteria.</p>","PeriodicalId":520929,"journal":{"name":"Smart molecules : open access","volume":"2 4","pages":"e20240037"},"PeriodicalIF":0.0000,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118169/pdf/","citationCount":"0","resultStr":"{\"title\":\"Metallo-supramolecular nanofibers based on type-I photosensitizer for synergistic antibacterial therapy.\",\"authors\":\"Shibo Lyu, Lukun Li, Jingdong Gao, Dapeng Liu, Fengling Song\",\"doi\":\"10.1002/smo.20240037\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Photodynamic therapy (PDT) has shown great merits in treating microbial infections due to its absence of bacterial resistance. However, the pronounced hypoxic microenvironment in the bacterial infections limits the therapeutic efficiency of traditional type-II PDT, which is highly dependent on oxygen. Here type-I photosensitizer BTZ<sub>n</sub>-Py (<i>n</i> = 8, 20) coordinates with chemical antibacterial agent Ag<sup>+</sup> to fabricate metallo-supramolecular nanofibers. Under light irradiation, the formed nanofibers could not only generate type-II reactive oxygen species (ROS), <sup>1</sup>O<sub>2</sub>, but also produce type-I ROS O<sub>2</sub> <sup>•-</sup> which addressed the hypoxic issues within infected tissues. Moreover, the acid- and photo-active Ag<sup>+</sup> release from the nanofibers endowed the metallo-supramolecular nanofibers with controlled release characteristic, which showed good biocompatibility to normal tissues. Owing to controlled Ag<sup>+</sup> release and photoinduced type-I ROS, the in vitro and in vivo experiments confirmed the significantly synergistic antibacterial performance of the metallo-supramolecular fibers against both Gram-positive and Gram-negative bacteria.</p>\",\"PeriodicalId\":520929,\"journal\":{\"name\":\"Smart molecules : open access\",\"volume\":\"2 4\",\"pages\":\"e20240037\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12118169/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Smart molecules : open access\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1002/smo.20240037\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Smart molecules : open access","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/smo.20240037","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Metallo-supramolecular nanofibers based on type-I photosensitizer for synergistic antibacterial therapy.
Photodynamic therapy (PDT) has shown great merits in treating microbial infections due to its absence of bacterial resistance. However, the pronounced hypoxic microenvironment in the bacterial infections limits the therapeutic efficiency of traditional type-II PDT, which is highly dependent on oxygen. Here type-I photosensitizer BTZn-Py (n = 8, 20) coordinates with chemical antibacterial agent Ag+ to fabricate metallo-supramolecular nanofibers. Under light irradiation, the formed nanofibers could not only generate type-II reactive oxygen species (ROS), 1O2, but also produce type-I ROS O2•- which addressed the hypoxic issues within infected tissues. Moreover, the acid- and photo-active Ag+ release from the nanofibers endowed the metallo-supramolecular nanofibers with controlled release characteristic, which showed good biocompatibility to normal tissues. Owing to controlled Ag+ release and photoinduced type-I ROS, the in vitro and in vivo experiments confirmed the significantly synergistic antibacterial performance of the metallo-supramolecular fibers against both Gram-positive and Gram-negative bacteria.