即使对功能恢复迟缓的仔猪，吸入6小时氢气也有神经保护作用。

IF 2.3 4区医学 Q2 DEVELOPMENTAL BIOLOGY

Developmental Neuroscience Pub Date : 2025-07-07 DOI:10.1159/000546831

Eri Inoue, Shinji Nakamura, Yuichiro Sugiyama, Toui Tsuchiya, Yasuhiro Nakao, Tsutomu Mitsuie, Takayuki Yokota, Kosuke Sakamoto, Kota Inoue, Yinmon Htun, Aya Morimoto, Kenichi Ohta, Hirosuke Morita, Sonoko Kondo, Kosuke Koyano, Aya Tanaka, Takanori Miki, Masaki Ueno, Takashi Kusaka

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引用次数: 0

摘要

与单独低温治疗相比，联合低温治疗和24小时氢（H2）气体吸入可减轻缺氧缺血性（HI）损伤潜伏期仔猪的癫痫发作负担。然而，复苏后早期H2气体的作用尚不清楚。方法：将17头≤24 h仔猪分为HI侮辱组（HI, n = 8）和HI + H2气体组（HI-H2, 2.1% ~ 2.7% H2气体，6 h, n = 9）。检测HI损伤后6小时恢复正常振幅综合脑电图背景（RT-aEEG）的时间，并计数未损伤的神经元。结果：低振幅持续时间(结论：复苏后6小时H2气体吸入组与未治疗组相比，未损伤神经元数量显著增加，但RT-aEEG无显著差异。即使对功能恢复迟缓的仔猪，吸入6小时氢气也有神经保护作用。

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Six Hours of Hydrogen Gas Inhalation Has a Neuroprotective Effect Even in Piglets with Delayed Functional Recovery.

Introduction: Combined therapeutic hypothermia (TH) and 24-h hydrogen (H2) gas inhalation reduces seizure burden in piglets in the latent phase of hypoxic-ischemic (HI) injury versus TH alone. Nevertheless, the effects of H2 gas in the earliest phase following resuscitation were unclear.

Methods: After HI insult, 17 piglets ≤ 24 h old were divided into a HI insult group (HI, n = 8) and a HI and H2 gas group (HI-H2, 2.1%-2.7% H2 gas, 6 h, n = 9). Time to recovery to a normal amplitude-integrated electroencephalogram background (RT-aEEG) was examined for 6 h after HI insult and undamaged neurons were counted.

Results: The duration of low-amplitude (<5 μV) EEG after insult was not different between the two groups. Undamaged neuron numbers were significantly higher in the HI-H2 group than in the HI group (p < 0.01), although RT-aEEG was not different.

Conclusion: Six hours of H2 gas inhalation initiated from resuscitation significantly increased the number of undamaged neurons compared to the untreated group, although there was no difference in RT-aEEG. Six hours of hydrogen gas inhalation exerts a neuroprotective effect even in piglets with delayed functional recovery.

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来源期刊

Developmental Neuroscience 医学-发育生物学

CiteScore

4.00

自引率

3.40%

发文量

审稿时长

>12 weeks

期刊介绍： ''Developmental Neuroscience'' is a multidisciplinary journal publishing papers covering all stages of invertebrate, vertebrate and human brain development. Emphasis is placed on publishing fundamental as well as translational studies that contribute to our understanding of mechanisms of normal development as well as genetic and environmental causes of abnormal brain development. The journal thus provides valuable information for both physicians and biologists. To meet the rapidly expanding information needs of its readers, the journal combines original papers that report on progress and advances in developmental neuroscience with concise mini-reviews that provide a timely overview of key topics, new insights and ongoing controversies. The editorial standards of ''Developmental Neuroscience'' are high. We are committed to publishing only high quality, complete papers that make significant contributions to the field.