{"title":"[巨食道测试对白瑞士牧羊犬有效吗?]","authors":"A Kehl, C Schelling","doi":"10.17236/sat00460","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Gene tests play an important role for controlling monogenetic diseases because they reveal a genotype for each tested dog and thereby allow for the selection of animals with a lower genetic burden. For some complex inherited diseases and anomalies so called risk-tests are available and may support the selection of breeding animals. They analyze DNA-sequence variants which render a higher risk for carriers to develop a disease or anomaly. The usefulness of a risk-test for congenital idiopathic megaoesophagus (CIM-test) in German shepherds was analyzed in the closely related breed of White Swiss shepherds. The results showed clearly that the CIM-test in this breed is almost not informative, and a selection would probably not reduce the prevalence but only lower the genetic variability. Breeders and owners should be informed accordingly.</p>","PeriodicalId":21544,"journal":{"name":"Schweizer Archiv fur Tierheilkunde","volume":"167 7","pages":"412-416"},"PeriodicalIF":0.8000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Is the megaesophagus test valid for White Swiss Shepherds (Berger Blanc Suisse)?]\",\"authors\":\"A Kehl, C Schelling\",\"doi\":\"10.17236/sat00460\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Gene tests play an important role for controlling monogenetic diseases because they reveal a genotype for each tested dog and thereby allow for the selection of animals with a lower genetic burden. For some complex inherited diseases and anomalies so called risk-tests are available and may support the selection of breeding animals. They analyze DNA-sequence variants which render a higher risk for carriers to develop a disease or anomaly. The usefulness of a risk-test for congenital idiopathic megaoesophagus (CIM-test) in German shepherds was analyzed in the closely related breed of White Swiss shepherds. The results showed clearly that the CIM-test in this breed is almost not informative, and a selection would probably not reduce the prevalence but only lower the genetic variability. Breeders and owners should be informed accordingly.</p>\",\"PeriodicalId\":21544,\"journal\":{\"name\":\"Schweizer Archiv fur Tierheilkunde\",\"volume\":\"167 7\",\"pages\":\"412-416\"},\"PeriodicalIF\":0.8000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Schweizer Archiv fur Tierheilkunde\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://doi.org/10.17236/sat00460\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Schweizer Archiv fur Tierheilkunde","FirstCategoryId":"97","ListUrlMain":"https://doi.org/10.17236/sat00460","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
[Is the megaesophagus test valid for White Swiss Shepherds (Berger Blanc Suisse)?]
Introduction: Gene tests play an important role for controlling monogenetic diseases because they reveal a genotype for each tested dog and thereby allow for the selection of animals with a lower genetic burden. For some complex inherited diseases and anomalies so called risk-tests are available and may support the selection of breeding animals. They analyze DNA-sequence variants which render a higher risk for carriers to develop a disease or anomaly. The usefulness of a risk-test for congenital idiopathic megaoesophagus (CIM-test) in German shepherds was analyzed in the closely related breed of White Swiss shepherds. The results showed clearly that the CIM-test in this breed is almost not informative, and a selection would probably not reduce the prevalence but only lower the genetic variability. Breeders and owners should be informed accordingly.
期刊介绍:
Das Schweizer Archiv für Tierheilkunde ist die älteste veterinärmedizinische Zeitschrift der Welt (gegründet 1816). Es ist das wissenschaftliche und praxisbezogene offizielle Publikationsorgan der Gesellschaft Schweizer Tierärztinnen und Tierärzte.