布里渊显微镜:眼科生物力学分析的新兴工具。

IF 3 3区 医学 Q1 OPHTHALMOLOGY
Jian Cao, Yanze Yu, Yong Ma, Xingtao Zhou, Jing Zhao
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引用次数: 0

摘要

目的:总结布里渊显微镜在眼科的临床和实验应用的最新进展,强调其在这些背景下促进生物力学理解的潜力。方法:文献复习。结果:布里渊显微镜采用可见光至近红外波长的低功率激光,通过分析布里渊频移,可以评估组织的纵向模量或粘弹性。这项技术为角膜的水合状态和各向异性生物力学提供了有价值的见解,提高了我们对其内在特征的理解。许多研究已经证明布里渊显微镜对角膜疾病的诊断潜力。实验研究也表明,在角膜瓣形成和角膜交联等过程中,布里渊生物力学特性发生了显著变化。此外,布里渊显微镜提供了一种新的视角来研究与年龄相关的布里渊生物力学和晶体晶体形态的变化。在离体研究中,布里渊测量已经成功地应用于其他眼部组织,包括角膜缘、巩膜和视网膜。结论:布里渊显微镜是一种很有前途的眼科工具。它提供了独特的见解,生物力学特性,疾病相关的眼部组织的改变,以及生物标本的内在特征。受激布里渊显微镜的应用,以及激光泵浦和机器学习技术的结合,可以进一步提高生物成像的采集速度和分辨率。[J].中华眼科杂志,2015;41(7):731- 746。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Brillouin Microscopy: An Emerging Tool for Biomechanical Analysis in Ophthalmology.

Purpose: To summarize recent progress in the clinical and experimental applications of Brillouin microscopy in ophthalmology, highlighting its potential to advance biomechanical understanding in these contexts.

Methods: Literature review.

Results: Employing low-power lasers across visible to near-infrared wavelengths, Brillouin microscopy enables the assessment of tissue's longitudinal modulus or viscoelasticity by analyzing the Brillouin frequency shift. This technique provides valuable insights into the cornea's hydration state and anisotropic biomechanics, improving our understanding of its intrinsic characteristics. Numerous studies have demonstrated the diagnostic potential of Brillouin microscopy for corneal diseases. Experimental research has also shown significant changes in Brillouin biomechanics properties following procedures like corneal flap formation and corneal cross-linking. Additionally, Brillouin microscopy offers a novel perspective on age-related changes in both Brillouin biomechanics and morphology of crystalline lenses. Successful Brillouin measurements have been performed on other ocular tissues, including the limbus, sclera, and retina, in ex vivo studies.

Conclusions: Brillouin microscopy holds great promise as an ophthalmology tool. It offers unique insights into the biomechanical properties, disease-related alterations in ocular tissues, and intrinsic characteristics of biological specimens. The application of stimulated Brillouin microscopy, along with the integration of laser pump and machine learning techniques, can further enhance the acquisition speed and resolution of biological imaging. [J Refract Surg. 2025;41(7):e731-e746.].

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来源期刊
CiteScore
5.10
自引率
12.50%
发文量
160
审稿时长
4-8 weeks
期刊介绍: The Journal of Refractive Surgery, the official journal of the International Society of Refractive Surgery, a partner of the American Academy of Ophthalmology, has been a monthly peer-reviewed forum for original research, review, and evaluation of refractive and lens-based surgical procedures for more than 30 years. Practical, clinically valuable articles provide readers with the most up-to-date information regarding advances in the field of refractive surgery. Begin to explore the Journal and all of its great benefits such as: • Columns including “Translational Science,” “Surgical Techniques,” and “Biomechanics” • Supplemental videos and materials available for many articles • Access to current articles, as well as several years of archived content • Articles posted online just 2 months after acceptance.
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