重度全频突发性感音神经性听力损失的预后分析及nomogram预测模型构建。

IF 0.8 4区医学 Q3 OTORHINOLARYNGOLOGY

Journal of Laryngology and Otology Pub Date : 2025-07-08 DOI:10.1017/S0022215125102582

Li Lijuan, Luo Jiasheng, Yang Yintong, Zhu Guanxia, Huo Meixu, Zhai Songyu, Song Shanghua

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引用次数: 0

摘要

目的：本研究旨在确定影响重度全频突发性感音神经性听力损失预后的因素，并开发一种早期预后工具。方法：对194例重度全频突发性感音神经性听力损失患者进行分析。单因素分析筛选变量，然后进行多因素logistic回归，构建nomogram预测模型。使用接收者工作特性曲线评估模型性能。结果：无效组与有效组在性别、年龄、对侧耳听力、听力损失持续时间、头晕/眩晕、高血压、血小板计数、纤维蛋白原水平（Fib1、Fib2、Fib3）等方面差异均有统计学意义（p < 0.05）。结合这些因素的nomogram模型具有良好的定标性。受试者工作特征曲线分析显示，曲线下面积为0.880(95%可信区间：0.829 ~ 0.931)，灵敏度为80.7%，特异性为87.5%。结论：综合11个因素的nomogram模型能有效预测重度全频突发性感音神经性听力损失患者的预后。

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Prognostic analysis and nomogram prediction model construction of severe full-frequency sudden sensorineural hearing loss.

Objectives: This stidy aimed to identify factors influencing prognosis in severe full-frequency sudden sensorineural hearing loss and develop an early prognostic tool.

Methods: A total of 194 patients with severe full-frequency sudden sensorineural hearing loss were analyzed. Univariate analysis screened variables, followed by multivariate logistic regression to construct a nomogram prediction model. Model performance was evaluated using a receiver operating characteristics curve.

Results: Significant differences (p < 0.05) were found between ineffective and effective treatment groups in gender, age, contralateral ear hearing, duration of hearing loss, dizziness/vertigo, hypertension, platelet count and fibrinogen levels (Fib1, Fib2, Fib3). The nomogram model, incorporating these factors, showed good calibration. The receiver operating characteristics curve analysis revealed an area under the curve of 0.880 (95 per cent confidence interval: 0.829-0.931), with sensitivity of 80.7 per cent and specificity of 87.5 per cent.

Conclusion: The nomogram model, integrating 11 factors, effectively predicts prognosis in severe full-frequency sudden sensorineural hearing loss.

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来源期刊

Journal of Laryngology and Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

11.80%

发文量

593

审稿时长

3-6 weeks

期刊介绍： The Journal of Laryngology & Otology (JLO) is a leading, monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialties. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area regardless of the country in which they practise. JLO contains main articles (original, review and historical), case reports and short reports as well as radiology, pathology or oncology in focus, a selection of abstracts, book reviews, letters to the editor, general notes and calendar, operative surgery techniques, and occasional supplements. It is fully illustrated and has become a definitive reference source in this fast-moving subject area. Published monthly an annual subscription is excellent value for money. Included in the subscription is access to the JLO interactive web site with searchable abstract database of the journal archive back to 1887.