Wenqian Qi, Junyan Han, Yu Cao, Hao Yu, Jingjing Hao, Ningning Yin, Xuefeng Zang, Lei Zhao, Wei Chen, Chen Chen, Hui Zeng, Jingyuan Liu, Ang Li
{"title":"脓毒症伴癌以骨髓细胞区室失调为标志:一项初步研究。","authors":"Wenqian Qi, Junyan Han, Yu Cao, Hao Yu, Jingjing Hao, Ningning Yin, Xuefeng Zang, Lei Zhao, Wei Chen, Chen Chen, Hui Zeng, Jingyuan Liu, Ang Li","doi":"10.2147/JIR.S523997","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Sepsis accounts for a significant proportion of global deaths and has limited treatment options. Cancer patients are at a higher risk of sepsis and experience worse outcomes, highlighting the complex interplay between sepsis and cancer on immune cell function and clinical prognosis.</p><p><strong>Methods: </strong>Between July and December 2023, we prospectively enrolled 30 sepsis patients and 10 healthy controls, categorizing the patients into sepsis with non-cancer and sepsis with cancer based on established clinical diagnostics. Multi-color flow cytometry was used to monitor changes in the expression of surface molecules of monocyte and neutrophil subsets, phagocytic activity and cytokine-producing capacity.</p><p><strong>Results: </strong>Compared with sepsis with non-cancer, the sepsis with cancer group demonstrated elevated 28-day mortality rates, increased CD177<sup>+</sup> activated band neutrophil and HLA-DR<sup>low</sup>CCR2<sup>low</sup> classical monocyte, and attenuated phagocytic activity of immature neutrophil and monocyte. Further, HLA-DR<sup>low</sup>CCR2<sup>low</sup> classical monocytes and CD177<sup>+</sup> myelocytes may serve as immunological predictors of adverse outcomes in sepsis. The HLA-DR<sup>low</sup>CCR2<sup>low</sup> classical monocyte and CD177<sup>+</sup> myelocytes exhibit significant correlations with internal environment and coagulation markers.</p><p><strong>Conclusion: </strong>In septic patients, particularly those patients with cancer, attenuated phagocytic activity of immature neutrophil (myelocytes, metamyelocytes, band neutrophils) and monocyte, and HLA-DR<sup>low</sup>CCR2<sup>low</sup> classical monocyte and CD177<sup>+</sup> myelocytes may serve as immunological predictors of poor prognosis.</p>","PeriodicalId":16107,"journal":{"name":"Journal of Inflammation Research","volume":"18 ","pages":"8643-8656"},"PeriodicalIF":4.2000,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230328/pdf/","citationCount":"0","resultStr":"{\"title\":\"Sepsis with Cancer is Marked by a Dysregulated Myeloid Cell Compartment: A Pilot Study.\",\"authors\":\"Wenqian Qi, Junyan Han, Yu Cao, Hao Yu, Jingjing Hao, Ningning Yin, Xuefeng Zang, Lei Zhao, Wei Chen, Chen Chen, Hui Zeng, Jingyuan Liu, Ang Li\",\"doi\":\"10.2147/JIR.S523997\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Sepsis accounts for a significant proportion of global deaths and has limited treatment options. Cancer patients are at a higher risk of sepsis and experience worse outcomes, highlighting the complex interplay between sepsis and cancer on immune cell function and clinical prognosis.</p><p><strong>Methods: </strong>Between July and December 2023, we prospectively enrolled 30 sepsis patients and 10 healthy controls, categorizing the patients into sepsis with non-cancer and sepsis with cancer based on established clinical diagnostics. Multi-color flow cytometry was used to monitor changes in the expression of surface molecules of monocyte and neutrophil subsets, phagocytic activity and cytokine-producing capacity.</p><p><strong>Results: </strong>Compared with sepsis with non-cancer, the sepsis with cancer group demonstrated elevated 28-day mortality rates, increased CD177<sup>+</sup> activated band neutrophil and HLA-DR<sup>low</sup>CCR2<sup>low</sup> classical monocyte, and attenuated phagocytic activity of immature neutrophil and monocyte. Further, HLA-DR<sup>low</sup>CCR2<sup>low</sup> classical monocytes and CD177<sup>+</sup> myelocytes may serve as immunological predictors of adverse outcomes in sepsis. The HLA-DR<sup>low</sup>CCR2<sup>low</sup> classical monocyte and CD177<sup>+</sup> myelocytes exhibit significant correlations with internal environment and coagulation markers.</p><p><strong>Conclusion: </strong>In septic patients, particularly those patients with cancer, attenuated phagocytic activity of immature neutrophil (myelocytes, metamyelocytes, band neutrophils) and monocyte, and HLA-DR<sup>low</sup>CCR2<sup>low</sup> classical monocyte and CD177<sup>+</sup> myelocytes may serve as immunological predictors of poor prognosis.</p>\",\"PeriodicalId\":16107,\"journal\":{\"name\":\"Journal of Inflammation Research\",\"volume\":\"18 \",\"pages\":\"8643-8656\"},\"PeriodicalIF\":4.2000,\"publicationDate\":\"2025-07-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230328/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Inflammation Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.2147/JIR.S523997\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/1/1 0:00:00\",\"PubModel\":\"eCollection\",\"JCR\":\"Q2\",\"JCRName\":\"IMMUNOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Inflammation Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/JIR.S523997","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
Sepsis with Cancer is Marked by a Dysregulated Myeloid Cell Compartment: A Pilot Study.
Background: Sepsis accounts for a significant proportion of global deaths and has limited treatment options. Cancer patients are at a higher risk of sepsis and experience worse outcomes, highlighting the complex interplay between sepsis and cancer on immune cell function and clinical prognosis.
Methods: Between July and December 2023, we prospectively enrolled 30 sepsis patients and 10 healthy controls, categorizing the patients into sepsis with non-cancer and sepsis with cancer based on established clinical diagnostics. Multi-color flow cytometry was used to monitor changes in the expression of surface molecules of monocyte and neutrophil subsets, phagocytic activity and cytokine-producing capacity.
Results: Compared with sepsis with non-cancer, the sepsis with cancer group demonstrated elevated 28-day mortality rates, increased CD177+ activated band neutrophil and HLA-DRlowCCR2low classical monocyte, and attenuated phagocytic activity of immature neutrophil and monocyte. Further, HLA-DRlowCCR2low classical monocytes and CD177+ myelocytes may serve as immunological predictors of adverse outcomes in sepsis. The HLA-DRlowCCR2low classical monocyte and CD177+ myelocytes exhibit significant correlations with internal environment and coagulation markers.
Conclusion: In septic patients, particularly those patients with cancer, attenuated phagocytic activity of immature neutrophil (myelocytes, metamyelocytes, band neutrophils) and monocyte, and HLA-DRlowCCR2low classical monocyte and CD177+ myelocytes may serve as immunological predictors of poor prognosis.
期刊介绍:
An international, peer-reviewed, open access, online journal that welcomes laboratory and clinical findings on the molecular basis, cell biology and pharmacology of inflammation.