胆囊癌的真实发病率:胰胆管畸形和胰胆管高汇合处的患病率。

IF 2.8 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Shintaro Shirai, Kenitiro Kaneko, Shoko Kato, Remi Kondo, Takaaki Osawa, Yasuyuki Fukami, Tsuyoshi Sano
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引用次数: 0

摘要

背景:虽然胰胆道畸形(PBM)与胆道癌的高发有关,但它经常未被诊断出来。这意味着PBM的真实患病率和胆道癌的发病率是未知的。胰胆管高合流(HCPBD)可能是一种中度PBM变体,尽管报道很少。在本研究中,我们旨在确定PBM和HCPBD的真实患病率以及胆道癌的实际发病率。方法:我们回顾性分析了因良性胆囊疾病接受胆囊切除术的成年人的资料,并将其与胆囊和胆管癌患者进行了比较。采用磁共振胆管造影测量共通道(CC)和窄远端段(NDS),诊断PBM和HCPBD。结果:在2046例良性胆囊切除术中,PBM和HCPBD的发生率分别为0.44%和0.88%,在胆囊癌中分别为16%和4.2%,在胆管癌中分别为1.3%和3.8% (p)。结合国家数据,PBM人群的胆囊癌发病率在十年内估计为2.4%,比普通人群高38倍。大约1%的人患有HCPBD,这可能是胆道癌的一个危险因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Prevalence of Pancreaticobiliary Maljunction and High Confluence of the Pancreaticobiliary Ducts: True Incidence of Gallbladder Cancer

Prevalence of Pancreaticobiliary Maljunction and High Confluence of the Pancreaticobiliary Ducts: True Incidence of Gallbladder Cancer

Background

Although pancreaticobiliary maljunction (PBM) is associated with a high incidence of biliary cancer, it often goes undiagnosed. This means that the true prevalence of PBM and the incidence of biliary cancer are unknown. High confluence of the pancreaticobiliary ducts (HCPBD) may be an intermediate PBM variant, though reports are scarce. In this study, we aimed to determine the true prevalence of PBM and HCPBD and the actual incidence of biliary cancer.

Methods

We retrospectively analyzed data from adults who underwent cholecystectomy for benign gallbladder disease and compared them to those with gallbladder and bile duct cancers. The common channel (CC) and narrow distal segment (NDS) were measured using magnetic resonance cholangiopancreatography to diagnose PBM and HCPBD.

Results

PBM and HCPBD were identified in 0.44% and 0.88% of 2046 benign cholecystectomies, 16% and 4.2% of gallbladder cancers, and 1.3% and 3.8% of bile duct cancers, respectively (p < 0.01).

Conclusions

The overall prevalence was 0.44%. Combined with national data, the gallbladder cancer incidence in PBM was estimated to be 2.4% over one decade, which is 38-fold higher than that in the general population. Approximately 1% of the population have HCPBD, which may be a risk factor for biliary cancer.

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来源期刊
Journal of Hepato‐Biliary‐Pancreatic Sciences
Journal of Hepato‐Biliary‐Pancreatic Sciences GASTROENTEROLOGY & HEPATOLOGY-SURGERY
自引率
10.00%
发文量
178
审稿时长
6-12 weeks
期刊介绍: The Journal of Hepato-Biliary-Pancreatic Sciences (JHBPS) is the leading peer-reviewed journal in the field of hepato-biliary-pancreatic sciences. JHBPS publishes articles dealing with clinical research as well as translational research on all aspects of this field. Coverage includes Original Article, Review Article, Images of Interest, Rapid Communication and an announcement section. Letters to the Editor and comments on the journal’s policies or content are also included. JHBPS welcomes submissions from surgeons, physicians, endoscopists, radiologists, oncologists, and pathologists.
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