生态失调和癌症之间的联系：促进机制和因素。

3区生物学 Q1 Biochemistry, Genetics and Molecular Biology

International review of cell and molecular biology Pub Date : 2025-01-01 Epub Date: 2025-01-20 DOI:10.1016/bs.ircmb.2024.12.004

Naimah Turner, Jocelynn Colunga-Minutti, Sayan Alekseev, Robert R Jenq, Roza Nurieva

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引用次数: 0

摘要

人类微生物群是一个复杂的生态系统，动态地与宿主系统相互作用。这种生态位的微妙平衡受到干扰，称为生态失调，可使个体易患多种疾病，包括癌症。特定微生物通过直接作用、调节宿主免疫系统和促进炎症参与致癌。此外，微生物群改变了抗癌治疗的反应和疗效。在这里，我们强调了生态失调促进癌症发生、进展和治疗的机制，以及微生物群如何能够靶向提高癌症预后。

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Link between dysbiosis and cancer: Contributing mechanisms and factors.

The human microbiota is a complex ecosystem that dynamically interacts with the host systemically. Perturbations in the delicate balance of this ecological niche, termed dysbiosis, can make individuals susceptible to a multitude of diseases, including cancer. Specific microbes have been implicated in carcinogenesis through direct effects, modulation of the host immune system, and by promoting inflammation. Furthermore, the microbiota alters the response to and efficacy of anti-cancer therapeutics. Here, we highlight mechanisms by which dysbiosis contributes to cancer development, progression, and therapy as well as how the microbiota can be targeted to enhance cancer outcomes.

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来源期刊

International review of cell and molecular biology BIOCHEMISTRY & MOLECULAR BIOLOGY-CELL BIOLOGY

CiteScore

7.70

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.