具有印戒细胞特征的原发性肺实体腺癌的诊断和临床挑战：1例罕见的临床表现和文献复习。

IF 0.5 Q4 ONCOLOGY

International Cancer Conference Journal Pub Date : 2025-05-09 eCollection Date: 2025-07-01 DOI:10.1007/s13691-025-00767-w

Noura A A Ebrahim, Moamen O Othman, Ahmed M Fahmy, Neveen S Tahoun, Rasha A Salama, Nermeen Mostafa Mahmoud, Habiba Elfandy

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引用次数: 0

摘要

具有印戒细胞特征的实体腺癌（SRCF）是一种极其罕见的肺腺癌变体，通常模仿其他部位的转移性肿瘤。准确的诊断在很大程度上依赖于免疫组织化学分析。本报告讨论一例实体性腺癌伴SRCF，表现为胸膜增厚，强调诊断挑战和治疗局限性。我们报告一个36岁的吸烟者进行性呼吸困难和胸膜痛。影像学显示胸膜增厚及肺结节。组织病理学示实性腺癌伴SRCF，免疫组化证实为原发性肺印戒细胞癌。尽管进行了化疗，但病情仍在恶化，患者在3个月内死亡。原发性肺实体腺癌合并SRCF具有高死亡率和诊断复杂性。免疫组织化学标记仍然是确定其肺部起源的关键。这一病例加强了对更好的诊断技术和治疗的迫切需要。图形化的简介:

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Diagnostic and clinical challenges of primary pulmonary solid adenocarcinoma with signet-ring cell features: a case report with unusual presentation and literature review.

Solid adenocarcinoma with signet-ring cell features (SRCF) is an extremely rare variant of lung adenocarcinoma, often mimicking metastatic tumors from other sites. Accurate diagnosis relies heavily on immunohistochemical profiling. This report discusses a case of solid adenocarcinoma with SRCF presenting with pleural thickening, highlighting diagnostic challenges and treatment limitations. We report a 36-year-old smoker with progressive dyspnea and pleuritic pain. Imaging revealed pleural thickening and pulmonary nodules. Histopathology showed solid adenocarcinoma with SRCF, confirmed by immunohistochemistry as primary pulmonary signet-ring cell carcinoma (SRCC). Despite chemotherapy, the disease progressed, and the patient succumbed within 3 months. Primary pulmonary solid adenocarcinoma with SRCF is associated with high mortality and diagnostic complexity. Immunohistochemical markers remain pivotal in establishing its pulmonary origin. This case reinforced the urgent need for better diagnostic techniques and therapies.

Graphical abstract:

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来源期刊

International Cancer Conference Journal ONCOLOGY-

自引率

14.30%

发文量

期刊介绍： This online-only journal publishes original case reports on all types of cancer. In particular, we welcome not only case reports of educational value in the diagnosis and treatment of cancers, but also reports on molecularly analyzed cancer cases, including gene mutations, gene fusions, gene expression, and changes in copy number, regardless of their known clinical significance. Assessing the molecular analysis of a tumor usually requires a “cancer conference” in which experts from various fields discuss it. Even if the authors and their respective “cancer conference” were unable to determine the clinical significance of molecular changes at the time of submission and publication, their data may provide evidence that will help the scientific community develop precision medicine solutions in the future. We welcome case reports with reviews of the literature on similar cases, as they are more useful and valuable to readers than are reports of rare cases. International Cancer Conference Journal is the official publication of the Japan Society of Clinical Oncology (JSCO). - Presents an online-only collection of original case reports on all types of cancer - In particular, welcomes molecularly analyzed cancer cases - The Official Publication of the Japan Society of Clinical Oncology (JSCO)