{"title":"全氟和多氟烷基物质（PFAS）与人类健康：全寿命暴露途径和潜在毒性综述。","authors":"Cindy Shin Ly Yeoh, Layan Abdulilah Alrazihi, Siew Tung Wong, Shew Fung Wong","doi":"10.1093/etojnl/vgaf172","DOIUrl":null,"url":null,"abstract":"<p><p>Research on toxicity, removal, and degradation of per- and polyfluoroalkyl substances (PFAS) has increased tremendously in the number of publications in recent years. The aim of this review was to summarize the source, exposure route, and potential toxicological effects of PFAS to humans. Relevant articles published between 2010 and 2022 were selected from PubMed and Scopus on the PFAS occurrence, exposure route, and potential toxicity effects on human health. This review discusses the potential exposure pathways to PFAS across various life stages, including contaminated food, drinking water, breastfeeding, indoor or outdoor air, and PFAS-containing consumer products. Furthermore, this paper highlights the possible associations between PFAS exposure and various health effects, and the mechanisms underlying these toxicological effects, including immune dysregulation and respiratory impacts, endocrine system disruptions (thyroid and pancreatic functions), lipid and metabolic dysregulation, systemic toxicities affecting the liver, cardiovascular system, and kidneys, as well as adverse reproductive and developmental outcomes, and the nervous system.</p>","PeriodicalId":11793,"journal":{"name":"Environmental Toxicology and Chemistry","volume":" ","pages":"2754-2786"},"PeriodicalIF":2.8000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Per- and poly-fluoroalkyl substances (PFAS) and human health: a review of exposure routes and potential toxicities across the lifespan.\",\"authors\":\"Cindy Shin Ly Yeoh, Layan Abdulilah Alrazihi, Siew Tung Wong, Shew Fung Wong\",\"doi\":\"10.1093/etojnl/vgaf172\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Research on toxicity, removal, and degradation of per- and polyfluoroalkyl substances (PFAS) has increased tremendously in the number of publications in recent years. The aim of this review was to summarize the source, exposure route, and potential toxicological effects of PFAS to humans. Relevant articles published between 2010 and 2022 were selected from PubMed and Scopus on the PFAS occurrence, exposure route, and potential toxicity effects on human health. This review discusses the potential exposure pathways to PFAS across various life stages, including contaminated food, drinking water, breastfeeding, indoor or outdoor air, and PFAS-containing consumer products. Furthermore, this paper highlights the possible associations between PFAS exposure and various health effects, and the mechanisms underlying these toxicological effects, including immune dysregulation and respiratory impacts, endocrine system disruptions (thyroid and pancreatic functions), lipid and metabolic dysregulation, systemic toxicities affecting the liver, cardiovascular system, and kidneys, as well as adverse reproductive and developmental outcomes, and the nervous system.</p>\",\"PeriodicalId\":11793,\"journal\":{\"name\":\"Environmental Toxicology and Chemistry\",\"volume\":\" \",\"pages\":\"2754-2786\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environmental Toxicology and Chemistry\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://doi.org/10.1093/etojnl/vgaf172\",\"RegionNum\":4,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Toxicology and Chemistry","FirstCategoryId":"93","ListUrlMain":"https://doi.org/10.1093/etojnl/vgaf172","RegionNum":4,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
Per- and poly-fluoroalkyl substances (PFAS) and human health: a review of exposure routes and potential toxicities across the lifespan.
Research on toxicity, removal, and degradation of per- and polyfluoroalkyl substances (PFAS) has increased tremendously in the number of publications in recent years. The aim of this review was to summarize the source, exposure route, and potential toxicological effects of PFAS to humans. Relevant articles published between 2010 and 2022 were selected from PubMed and Scopus on the PFAS occurrence, exposure route, and potential toxicity effects on human health. This review discusses the potential exposure pathways to PFAS across various life stages, including contaminated food, drinking water, breastfeeding, indoor or outdoor air, and PFAS-containing consumer products. Furthermore, this paper highlights the possible associations between PFAS exposure and various health effects, and the mechanisms underlying these toxicological effects, including immune dysregulation and respiratory impacts, endocrine system disruptions (thyroid and pancreatic functions), lipid and metabolic dysregulation, systemic toxicities affecting the liver, cardiovascular system, and kidneys, as well as adverse reproductive and developmental outcomes, and the nervous system.
期刊介绍：
The Society of Environmental Toxicology and Chemistry (SETAC) publishes two journals: Environmental Toxicology and Chemistry (ET&C) and Integrated Environmental Assessment and Management (IEAM). Environmental Toxicology and Chemistry is dedicated to furthering scientific knowledge and disseminating information on environmental toxicology and chemistry, including the application of these sciences to risk assessment.[...]
Environmental Toxicology and Chemistry is interdisciplinary in scope and integrates the fields of environmental toxicology; environmental, analytical, and molecular chemistry; ecology; physiology; biochemistry; microbiology; genetics; genomics; environmental engineering; chemical, environmental, and biological modeling; epidemiology; and earth sciences. ET&C seeks to publish papers describing original experimental or theoretical work that significantly advances understanding in the area of environmental toxicology, environmental chemistry and hazard/risk assessment. Emphasis is given to papers that enhance capabilities for the prediction, measurement, and assessment of the fate and effects of chemicals in the environment, rather than simply providing additional data. The scientific impact of papers is judged in terms of the breadth and depth of the findings and the expected influence on existing or future scientific practice. Methodological papers must make clear not only how the work differs from existing practice, but the significance of these differences to the field. Site-based research or monitoring must have regional or global implications beyond the particular site, such as evaluating processes, mechanisms, or theory under a natural environmental setting.
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