微颗粒形状揭示了经动脉栓塞治疗的长期颗粒血管内稳定性的关键作用。

IF 5.4 2区 医学 Q2 MATERIALS SCIENCE, BIOMATERIALS
Man Huang, Zijian Chen, Yutao Ma, Yingnan Li, Zhihua Li, Runyuan Wang, Yiqi Zhang, Qiongyu Guo
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引用次数: 0

摘要

经动脉栓塞(TAE)是一种广泛应用于治疗各种病变血管状况的介入手术,包括肿瘤和动静脉畸形。TAE的成功在很大程度上依赖于栓塞剂封堵靶血管的有效性和稳定性。虽然对栓塞颗粒的材料和大小给予了相当大的关注,但颗粒形状在血管内稳定性中的作用却很少被探索。本研究探讨了栓塞颗粒的几何特性如何影响它们在血管系统中的行为,特别是在它们部署后的保留、分布和整体稳定性方面。我们证明颗粒形状显著影响栓塞剂的动力学,胶囊状颗粒表现出增强对血管壁的粘附性,减少迁移的可能性,提高长期闭塞的稳定性。相反,球形颗粒更容易脱位,导致次优栓塞和潜在并发症。这些发现强调了颗粒形状在优化TAE血管内稳定性中的重要性,表明具有特定形态特性的定制栓塞剂可以通过增强治疗的持久性和有效性来改善临床结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Microparticle Shape Reveals a Key Role in Long-Term Particulate Endovascular Stability of Transarterial Embolization Treatment.

Transarterial embolization (TAE) is a widely used interventional procedure for treating various diseased vascular conditions, including tumors and arteriovenous malformations. The success of the TAE relies heavily on the effectiveness and stability of embolic agents used to occlude target vessels. While considerable attention has been given to the material and size of embolic particles, the role of the particulate shape in endovascular stability has been less explored. This study investigates how the geometric properties of embolic particles influence their behavior within the vascular system, particularly regarding their retention, distribution, and overall stability after deployment. We demonstrate that particle shape significantly affects the dynamics of embolic agents, with capsule-shaped particles exhibiting enhanced adherence to vessel walls, reducing the likelihood of migration and improving the long-term occlusion stability. In contrast, spherical particles are more prone to dislodgement, leading to suboptimal embolization and potential complications. These findings underscore the critical importance of particulate shape in optimizing the endovascular stability of TAE, suggesting that tailored embolic agents with specific morphological properties could improve clinical outcomes by enhancing the treatment's durability and efficacy.

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来源期刊
ACS Biomaterials Science & Engineering
ACS Biomaterials Science & Engineering Materials Science-Biomaterials
CiteScore
10.30
自引率
3.40%
发文量
413
期刊介绍: ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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