{"title":"微颗粒形状揭示了经动脉栓塞治疗的长期颗粒血管内稳定性的关键作用。","authors":"Man Huang, Zijian Chen, Yutao Ma, Yingnan Li, Zhihua Li, Runyuan Wang, Yiqi Zhang, Qiongyu Guo","doi":"10.1021/acsbiomaterials.5c00639","DOIUrl":null,"url":null,"abstract":"<p><p>Transarterial embolization (TAE) is a widely used interventional procedure for treating various diseased vascular conditions, including tumors and arteriovenous malformations. The success of the TAE relies heavily on the effectiveness and stability of embolic agents used to occlude target vessels. While considerable attention has been given to the material and size of embolic particles, the role of the particulate shape in endovascular stability has been less explored. This study investigates how the geometric properties of embolic particles influence their behavior within the vascular system, particularly regarding their retention, distribution, and overall stability after deployment. We demonstrate that particle shape significantly affects the dynamics of embolic agents, with capsule-shaped particles exhibiting enhanced adherence to vessel walls, reducing the likelihood of migration and improving the long-term occlusion stability. In contrast, spherical particles are more prone to dislodgement, leading to suboptimal embolization and potential complications. These findings underscore the critical importance of particulate shape in optimizing the endovascular stability of TAE, suggesting that tailored embolic agents with specific morphological properties could improve clinical outcomes by enhancing the treatment's durability and efficacy.</p>","PeriodicalId":8,"journal":{"name":"ACS Biomaterials Science & Engineering","volume":" ","pages":""},"PeriodicalIF":5.4000,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Microparticle Shape Reveals a Key Role in Long-Term Particulate Endovascular Stability of Transarterial Embolization Treatment.\",\"authors\":\"Man Huang, Zijian Chen, Yutao Ma, Yingnan Li, Zhihua Li, Runyuan Wang, Yiqi Zhang, Qiongyu Guo\",\"doi\":\"10.1021/acsbiomaterials.5c00639\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Transarterial embolization (TAE) is a widely used interventional procedure for treating various diseased vascular conditions, including tumors and arteriovenous malformations. The success of the TAE relies heavily on the effectiveness and stability of embolic agents used to occlude target vessels. While considerable attention has been given to the material and size of embolic particles, the role of the particulate shape in endovascular stability has been less explored. This study investigates how the geometric properties of embolic particles influence their behavior within the vascular system, particularly regarding their retention, distribution, and overall stability after deployment. We demonstrate that particle shape significantly affects the dynamics of embolic agents, with capsule-shaped particles exhibiting enhanced adherence to vessel walls, reducing the likelihood of migration and improving the long-term occlusion stability. In contrast, spherical particles are more prone to dislodgement, leading to suboptimal embolization and potential complications. These findings underscore the critical importance of particulate shape in optimizing the endovascular stability of TAE, suggesting that tailored embolic agents with specific morphological properties could improve clinical outcomes by enhancing the treatment's durability and efficacy.</p>\",\"PeriodicalId\":8,\"journal\":{\"name\":\"ACS Biomaterials Science & Engineering\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2025-07-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Biomaterials Science & Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1021/acsbiomaterials.5c00639\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, BIOMATERIALS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Biomaterials Science & Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1021/acsbiomaterials.5c00639","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, BIOMATERIALS","Score":null,"Total":0}
Microparticle Shape Reveals a Key Role in Long-Term Particulate Endovascular Stability of Transarterial Embolization Treatment.
Transarterial embolization (TAE) is a widely used interventional procedure for treating various diseased vascular conditions, including tumors and arteriovenous malformations. The success of the TAE relies heavily on the effectiveness and stability of embolic agents used to occlude target vessels. While considerable attention has been given to the material and size of embolic particles, the role of the particulate shape in endovascular stability has been less explored. This study investigates how the geometric properties of embolic particles influence their behavior within the vascular system, particularly regarding their retention, distribution, and overall stability after deployment. We demonstrate that particle shape significantly affects the dynamics of embolic agents, with capsule-shaped particles exhibiting enhanced adherence to vessel walls, reducing the likelihood of migration and improving the long-term occlusion stability. In contrast, spherical particles are more prone to dislodgement, leading to suboptimal embolization and potential complications. These findings underscore the critical importance of particulate shape in optimizing the endovascular stability of TAE, suggesting that tailored embolic agents with specific morphological properties could improve clinical outcomes by enhancing the treatment's durability and efficacy.
期刊介绍:
ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics:
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Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions
Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis
Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering
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Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials
Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture