Mousso Savadogo, Lassina Traoré, Abdou Azaque Zouré, Touwendpoulimdé Isabelle Kiendrebeogo, Pegdwende Abel Sorgho, Soayebo Dabre, Aida Djé Djénéba Traore, Sidonie Ilboudo, Nafissatou Sanon, Marc Donald Wilfried Adico, Minane Nafissa Triande, Teega-Wendé Clarisse Ouedraogo, Rogomenoma Alice Ouedraogo, Alexis Yobi Sawadogo, Nayi Zongo, Hierrhum Aboubacar Bambara, Christelle M. W. Nadembega, Florencia W. Djigma, Jacques Simpore
{"title":"MAP3K14基因rs2074292和CD40基因rs1883832多态性与布基纳法索妇女乳腺癌:一项病例对照研究","authors":"Mousso Savadogo, Lassina Traoré, Abdou Azaque Zouré, Touwendpoulimdé Isabelle Kiendrebeogo, Pegdwende Abel Sorgho, Soayebo Dabre, Aida Djé Djénéba Traore, Sidonie Ilboudo, Nafissatou Sanon, Marc Donald Wilfried Adico, Minane Nafissa Triande, Teega-Wendé Clarisse Ouedraogo, Rogomenoma Alice Ouedraogo, Alexis Yobi Sawadogo, Nayi Zongo, Hierrhum Aboubacar Bambara, Christelle M. W. Nadembega, Florencia W. Djigma, Jacques Simpore","doi":"10.1002/hsr2.71027","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background Aims</h3>\n \n <p>The leading mammary cancer in Burkina Faso, breast cancer has a variety of origins. In fact, an alteration in the <i>MAP3K14</i> [GenBank: NC_000017.11, ID: 9020] and CD40 [GenBank: NC_000020.11, ID: 958] genes can lead to the development of breast cancer. The goal of this study is to highlight the possible involvement of the polymorphisms rs2074292 in the <i>MAP3K14</i> gene and rs1883832 in the <i>CD40</i> gene in the development of breast cancer in women in Burkina Faso.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>One hundred and fifty-two (152) participants, including 71 patients versus 81 controls, took part in this case-control study. Real-time PCR was used for genotyping the two polymorphisms (rs2074292 and rs1883832), and the <i>χ</i><sup>2</sup> test was used for risk assessment by calculating odds ratios, confidence intervals, and <i>p</i> values.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>For the <i>MAP3K14</i> gene, the allelic frequencies A and G, were respectively 54.40%, 35.25% in cases and 45.60%, 64.75% in controls. For the <i>CD40</i> gene, the C and T allelic frequencies were 48.15% and 35.29% in the cases and 51.85% and 64.71% in the controls, respectively. The rs2074292 polymorphism of the <i>MAP3K14</i> gene confers protection breast cancer with respectively the allele G (OR = 0.45 CI (95%) = 0.28–0.73; <i>p</i> = 0.01) and the heterozygote genotype AG (OR = 0.08 CI (95%) = 0.02–0.024; <i>p</i> < 0.01) while, no association was established between the rs1883832 polymorphism of the <i>CD40</i> gene and the occurrence of breast cancer (OR = 0.58 CI (95%) = 0.27–1.23; <i>p</i> = 0.15).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>The rs2074292 polymorphism of the <i>MAP3K14</i> gene protects against progression to breast cancer in Burkina Faso. This study, therefore, contributes to an understanding of the role played by these two polymorphisms in the pathogenesis of this devastating disease.</p>\n </section>\n </div>","PeriodicalId":36518,"journal":{"name":"Health Science Reports","volume":"8 7","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.71027","citationCount":"0","resultStr":"{\"title\":\"Polymorphisms rs2074292 of the MAP3K14 Gene and rs1883832 of the CD40 Gene and Breast Cancer in Women in Burkina Faso: A Case-Control Study\",\"authors\":\"Mousso Savadogo, Lassina Traoré, Abdou Azaque Zouré, Touwendpoulimdé Isabelle Kiendrebeogo, Pegdwende Abel Sorgho, Soayebo Dabre, Aida Djé Djénéba Traore, Sidonie Ilboudo, Nafissatou Sanon, Marc Donald Wilfried Adico, Minane Nafissa Triande, Teega-Wendé Clarisse Ouedraogo, Rogomenoma Alice Ouedraogo, Alexis Yobi Sawadogo, Nayi Zongo, Hierrhum Aboubacar Bambara, Christelle M. W. Nadembega, Florencia W. Djigma, Jacques Simpore\",\"doi\":\"10.1002/hsr2.71027\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background Aims</h3>\\n \\n <p>The leading mammary cancer in Burkina Faso, breast cancer has a variety of origins. In fact, an alteration in the <i>MAP3K14</i> [GenBank: NC_000017.11, ID: 9020] and CD40 [GenBank: NC_000020.11, ID: 958] genes can lead to the development of breast cancer. The goal of this study is to highlight the possible involvement of the polymorphisms rs2074292 in the <i>MAP3K14</i> gene and rs1883832 in the <i>CD40</i> gene in the development of breast cancer in women in Burkina Faso.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>One hundred and fifty-two (152) participants, including 71 patients versus 81 controls, took part in this case-control study. Real-time PCR was used for genotyping the two polymorphisms (rs2074292 and rs1883832), and the <i>χ</i><sup>2</sup> test was used for risk assessment by calculating odds ratios, confidence intervals, and <i>p</i> values.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>For the <i>MAP3K14</i> gene, the allelic frequencies A and G, were respectively 54.40%, 35.25% in cases and 45.60%, 64.75% in controls. For the <i>CD40</i> gene, the C and T allelic frequencies were 48.15% and 35.29% in the cases and 51.85% and 64.71% in the controls, respectively. The rs2074292 polymorphism of the <i>MAP3K14</i> gene confers protection breast cancer with respectively the allele G (OR = 0.45 CI (95%) = 0.28–0.73; <i>p</i> = 0.01) and the heterozygote genotype AG (OR = 0.08 CI (95%) = 0.02–0.024; <i>p</i> < 0.01) while, no association was established between the rs1883832 polymorphism of the <i>CD40</i> gene and the occurrence of breast cancer (OR = 0.58 CI (95%) = 0.27–1.23; <i>p</i> = 0.15).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>The rs2074292 polymorphism of the <i>MAP3K14</i> gene protects against progression to breast cancer in Burkina Faso. This study, therefore, contributes to an understanding of the role played by these two polymorphisms in the pathogenesis of this devastating disease.</p>\\n </section>\\n </div>\",\"PeriodicalId\":36518,\"journal\":{\"name\":\"Health Science Reports\",\"volume\":\"8 7\",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-07-09\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hsr2.71027\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Health Science Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/hsr2.71027\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Health Science Reports","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/hsr2.71027","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
Polymorphisms rs2074292 of the MAP3K14 Gene and rs1883832 of the CD40 Gene and Breast Cancer in Women in Burkina Faso: A Case-Control Study
Background Aims
The leading mammary cancer in Burkina Faso, breast cancer has a variety of origins. In fact, an alteration in the MAP3K14 [GenBank: NC_000017.11, ID: 9020] and CD40 [GenBank: NC_000020.11, ID: 958] genes can lead to the development of breast cancer. The goal of this study is to highlight the possible involvement of the polymorphisms rs2074292 in the MAP3K14 gene and rs1883832 in the CD40 gene in the development of breast cancer in women in Burkina Faso.
Methods
One hundred and fifty-two (152) participants, including 71 patients versus 81 controls, took part in this case-control study. Real-time PCR was used for genotyping the two polymorphisms (rs2074292 and rs1883832), and the χ2 test was used for risk assessment by calculating odds ratios, confidence intervals, and p values.
Results
For the MAP3K14 gene, the allelic frequencies A and G, were respectively 54.40%, 35.25% in cases and 45.60%, 64.75% in controls. For the CD40 gene, the C and T allelic frequencies were 48.15% and 35.29% in the cases and 51.85% and 64.71% in the controls, respectively. The rs2074292 polymorphism of the MAP3K14 gene confers protection breast cancer with respectively the allele G (OR = 0.45 CI (95%) = 0.28–0.73; p = 0.01) and the heterozygote genotype AG (OR = 0.08 CI (95%) = 0.02–0.024; p < 0.01) while, no association was established between the rs1883832 polymorphism of the CD40 gene and the occurrence of breast cancer (OR = 0.58 CI (95%) = 0.27–1.23; p = 0.15).
Conclusion
The rs2074292 polymorphism of the MAP3K14 gene protects against progression to breast cancer in Burkina Faso. This study, therefore, contributes to an understanding of the role played by these two polymorphisms in the pathogenesis of this devastating disease.